Volume 28, Issue 149, July 2024

About the Cover

Uveal melanoma (UM) is a sparse tumor situated inside the eyeball. It occurs more often in adults but can appear also in children. The location of the neoplasm, which implies difficulties in access, the severe course of the disease, and unfavorable prognosis for patients, especially in an advanced stage of the disease, make uveal melanoma a medical challenge. Therefore, early detection of a lesion and immediate treatment are so significant. Available methods include conservative and surgical ones. Primary tumor therapy includes radiotherapy, surgical resection, photocoagulation, transpupillary thermotherapy, and photodynamic therapy. In turn, treatment of metastases, most often affecting the liver, involves: Metastasectomy, radio-, immuno- and chemoembolisation, isolated or percutaneous hepatic perfusion, and molecular targeted therapy. The last mentioned is a developing and promising field of study. A breakthrough step in recent years was the registration of tabentafusp, the first monoclonal antibody and the first molecule for the therapy of metastatic disease. This article summarizes crucial information regarding currently implemented therapeutical approaches, novel molecules, and solutions that are the subject of research.

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REVIEW

Therapeutic strategies in Uveal Melanoma: A comprehensive review of primary and metastatic disease treatment approaches

Natalia Paduszyńska, Anna Dąbrowska, Adrian Kruszewski, Karolina Błaszczak, Paulina Przybysz, Monika Szyszka, Maja Kucharska

Uveal melanoma (UM) is a sparse tumor situated inside the eyeball. It occurs more often in adults but can appear also in children. The location of the neoplasm, which implies difficulties in access, the severe course of the disease

Medical Science, 2024, 28, e68ms3370

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Molecular insights and treatment approaches for a common childhood tumor – Medulloblastoma decoded: A review

Magdalena Iwan, Błażej Szymczuk, Dominik Trojanowski, Jakub Milczarek, Ksawery Adamiec, Joanna Smorońska-Rypel, Małgorzata Rodak, Magdalena Kajzar, Kamila Nitka, Natalia Piątkowska

Introduction: Medulloblastoma is the most common tumor of the central nervous system in children. Advances in medicine have allowed for the identification of molecular subtypes of this tumor, which determine patient prognosis and further therapeutic approaches

Medical Science, 2024, 28, e69ms3378

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ARTICLE

The effects of hemoperfusion on the recovery of COVID-19 patients: A pilot trial

Saman Farshid, Mohammadreza Doosti Rezaei, Khadijeh Makhdoomi, Behdad Broofeh, Mahdi Hemmati Ghavshough

Background: As a treatment method, considerable amounts of patients' blood are transferred to absorbents to remove blood cytokines in hemoperfusion. The present research studies the contribution of hemoperfusion to the outcomes observed in patients with COVID-19.

Medical Science, 2024, 28, e70ms3372

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Comparison of the age of cardiovascular diseases among military personnel with other occupational groups

Yousef Alimohamadi, Hadi Jalilvand, Mojtaba Sepandi

Introduction: Military personnel, as one of the most essential occupational groups, are at a risk of developing cardiovascular diseases

Medical Science, 2024, 28, e71ms3377

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REVIEW

Binge Eating Disorder and Loss-of-control Eating following bariatric surgery: An update on research

Jan Kościan, Maria Mitkowska, Zuzanna Dryżałowska, Michał Obrębski, Karolina Szczerkowska, Justyna Chwiejczak, Aleksander Górny, Anna Seroka, Maria Rybicka, Julita Młynarska, Anna Wójcik

Bariatric surgery remains a leading treatment for obesity due to its effectiveness in reducing food intake. However, outcomes may be influenced by various factors, and some patients fail to achieve desired weight reduction

Medical Science, 2024, 28, e72ms3375

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ARTICLE

Prescribing aerobic exercise for patients with wearable devices – a practical approach for healthcare providers

Wiktor Biłat, Magdalena Woźniak

Purpose: Most studies use VO2 max as a marker for exercise intensity; however, it is impossible to measure daily. The rising popularity of heart rate monitoring wearable devices could offer a more accessible way of exercise intensity monitoring and prescribing activity by healthcare providers

Medical Science, 2024, 28, e73ms3381

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CASE REPORT

A GIST tumor mimicking an ovarian tumor diagnosed intraoperatively: A 50-years-old woman case study

Anna Józefiak, Magdalena Szczepanik, Gabriela Mazurek, Maciej Horbaczewski, Przemysław Hałasiński, Dominika Kropidłowska, Maria Myślicka, Jolanta Mazurek, Kinga Piela, Cezary Bochyński, Patryk Góralski, Olgierd Betcher, Ruslan Zavatskyi

Introduction: Neoplastic growths involving women's genital organs, such as uterine myomas and ovarian tumors, are the most common benign lesions occurring in the mid-and lower abdominal regions

Medical Science, 2024, 28, e74ms3385

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ARTICLE

Optimizing sample size estimation and statistical analysis in health sciences: A comprehensive guide using the S2SAC tool

Mohamad Arif Awang Nawi

Statistical errors in health sciences research can greatly undermine the dependability of study results, negatively impacting clinical decision-making and policy development

Medical Science, 2024, 28, e75ms3380

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REVIEW

Dermatomyositis - the impact of quick diagnosis and treatment on the development of the disease. A review of current research

Magdalena Kajzar, Błażej Szymczuk, Dominik Trojanowski, Jakub Milczarek, Ksawery Adamiec, Joanna Smorońska-Rypel, Małgorzata Rodak, Magdalena Iwan, Kamila Nitka, Natalia Piątkowska

Introduction: Dermatomyositis (DM) is an inflammatory disease classified among autoimmune diseases affecting young and older individuals

Medical Science, 2024, 28, e76ms3388

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Long term effects of mechanical ventilation on lung function in critical care patients: Systematic review

Hussain Al-Haji, Jalal Al-Qahtani, Ali Nasser Al-Aliani, Othman Khalid Abahoussin, Tariq Alshehri, Mohammed Al-Mesned, Thamer Awadh Alanazi, Yasser Al-Shammari, Ahmad Al-Aqeily

Background: Weaning the patient off the ventilator becomes difficult when the diaphragm contraction ability deteriorates, which often occurs after a prolonged period of mechanical ventilation

Medical Science, 2024, 28, e77ms3392

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Effectiveness of Bilevel positive airway pressure ventilation for acute respiratory failure patients: A systematic review

Mohammed Ayed Algamdi, Mohammed Saleh Almulhim, Abdullah Sultan Alangari, Saud Abdullah Alsalem, Abdulaziz Fahad Alkharji, Khalid Mefleh Alrasheedi, Abdulkarim Farhan Alanazi, Wael Mohammed Alqahtani, Fahad Mohammed Alsahli, Khalid Rikaa Almatrafi

Background: It's uncertain if BiPAP helps people with acute respiratory failure. This research aims to determine if BiPAP is effective for people with acute respiratory failure

Medical Science, 2024, 28, e78ms3394

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ARTICLE

Pattern of burn injuries and short-term outcome of management in a limited resources area

Siddig Fadul Mohamed Ahmed, Mohamed Elfatih M Elhaj, Ahmed Elamin Elsheikh, Hammad Ali Fadlalmola

Burn injuries are a significant global public health issue, ranking as the fourth most common type of trauma after traffic accidents, falls, and interpersonal violence

Medical Science, 2024, 28, e79ms3364

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REVIEW

Relationship between sexual issues, gender identity, and autism spectrum disorder: A review

Klaudia Włodarczyk, Maria Myślicka, Milena Orzeł, Bartłomiej Orzeł, Anna Józefiak, Magdalena Szczepanik, Gabriela Mazurek, Dominika Kropidłowska, Przemysław Hałasiński, Jolanta Mazurek, Kinga Piela, Cezary Bochyński

Introduction: An individual's innate sense of their gender is known as gender identity. If someone identifies with the gender they were born with, that person is referred to as "Cisgender".

Medical Science, 2024, 28, e80ms3383

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Extracorporeal membrane oxygenation outcome in adults with acute respiratory distress: Systematic review

Khalaf Awayed Alanazi, Abdulmohsen Jurbua Alanazi, Ghadah Saleh Almahyobi, Manal Ali Alanazi, Hashem Fawzi Alsamannoudi, Arwa Hajea Alanazi, Nawaf Abdulkarim Alnaam, Naif Almohaimid, Ahmed Ali Majrashi, Mohammed Obaid Alenazi

Background: An increased death risk is associated with acute respiratory distress syndrome. For patients with advanced respiratory and circulatory problems, ECMO provides temporary heart and lung replacement as well as breathing support

Medical Science, 2024, 28, e81ms3393

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Can Lyme disease manifest and progress differently in children? - a review

Kamila Nitka, Joanna Smorońska-Rypel, Małgorzata Rodak, Magdalena Kajzar, Natalia Piątkowska, Magdalena Iwan, Błażej Szymczuk, Dominik Trojanowski, Jakub Milczarek, Ksawery Adamiec

One of the most common zoonoses in humans and the most well-known tickborne disease—Lyme disease—affects many body systems

Medical Science, 2024, 28, e82ms3384

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Is there a role for probiotics in prevention and treatment of allergic diseases in children? – review of literature

Aleksandra Kublińska, Roksana Zdunek, Sylwia Mazur, Natalia Dąbrowska, Karolina Strus, Emilia Nagórska, Magdalena Madera, Aleksy Bizan, Agata Mazur, Krzysztof Marcinkowski

Allergic diseases in the pediatric population are a significant burden to healthcare systems, families, and children themselves. They decrease patients’ quality of life

Medical Science, 2024, 28, e83ms3390

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Biomarkers in Rheumatoid Arthritis. Review of the current state of knowledge

Adrian Kruszewski, Natalia Paduszyńska, Anna Dąbrowska, Barbara Wawrzyńska, Karolina Strus, Roksana Zdunek, Magdalena Madera

Rheumatic arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation and joint destruction.

Medical Science, 2024, 28, e84ms3389

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CASE REPORT

Wunderlich Syndrome - misdiagnosed mystery: Introduction and case report

Kinga Piela, Cezary Bochyński, Jolanta Mazurek, Anna Józefiak, Magdalena Szczepanik, Gabriela Mazurek, Maciej Horbaczewski, Przemysław Hałasiński, Dominika Kropidłowska, Maria Myślicka, Patryk Góralski, Klaudia Włodarczyk

Introduction: Wunderlich syndrome is a spontaneous, nontraumatic, and rare subcapsular perinephric hematoma. Since 2013, only about 280 cases have been reported

Medical Science, 2024, 28, e85ms3387

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ARTICLE

Exploring the Prevalence of Constipation in Diabetic Individuals in Qassim Region, Saudi Arabia 2024

Muath A Aloufi, Qobayel Q Alqahtani, Bashaer A Albedah

Introduction: Constipation is prevalent worldwide (6.6%-10.1%). Its association with diabetes mellitus (DM) is clear; it affects the quality of life, and diabetic complications could potentially worsen

Medical Science, 2024, 28, e86ms3396

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REVIEW

Quality management among healthcare professionals in Saudi Arabia: Systematic review

Abdulaziz Alkhrisi, Khalid Alanazi, Abdulelah Alzahrani, Rayan Almutairi, Muath Alahmari, Ahmad Alkanhal

Background: Quality Management has become one of the most studied factors in the last decade, including in the healthcare sector. The aim of this study is to assess the awareness of quality management among healthcare professionals in KSA in the period 2014 to 2024

Medical Science, 2024, 28, e87ms3373

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Nephrolithiasis - risk factors, prevention, diagnostic and treatment problem of the 21st century - review of the literature

Natalia Sak, Przemysław Hałasiński, Dagmara Skowrońska, Max Tschuschke, Mikołaj Lorenz

Worldwide, the incidence of kidney stones is increasing rapidly. This relationship is also noticeable with age. Its occurrence is associated with chronic kidney disease.

Medical Science, 2024, 28, e88ms3398

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