Volume 28, Issue 149, July 2024

Therapeutic strategies in Uveal Melanoma: A comprehensive review of primary and metastatic disease treatment approaches

Natalia Paduszyńska^1♦, Anna Dąbrowska¹, Adrian Kruszewski¹, Karolina Błaszczak¹, Paulina Przybysz², Monika Szyszka³, Maja Kucharska³

¹Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland
²University Clinical Centre of the Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland
³Regional Specialist Hospital in Ciechanów, Powstańców Wielkopolskich 2, 06-400 Ciechanów, Poland

^♦Corresponding Author
Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland

ABSTRACT

Uveal melanoma (UM) is a sparse tumor situated inside the eyeball. It occurs more often in adults but can appear also in children. The location of the neoplasm, which implies difficulties in access, the severe course of the disease, and unfavorable prognosis for patients, especially in an advanced stage of the disease, make uveal melanoma a medical challenge. Therefore, early detection of a lesion and immediate treatment are so significant. Available methods include conservative and surgical ones. Primary tumor therapy includes radiotherapy, surgical resection, photocoagulation, transpupillary thermotherapy, and photodynamic therapy. In turn, treatment of metastases, most often affecting the liver, involves: Metastasectomy, radio-, immuno- and chemoembolisation, isolated or percutaneous hepatic perfusion, and molecular targeted therapy. The last mentioned is a developing and promising field of study. A breakthrough step in recent years was the registration of tabentafusp, the first monoclonal antibody and the first molecule for the therapy of metastatic disease. This article summarizes crucial information regarding currently implemented therapeutical approaches, novel molecules, and solutions that are the subject of research.

Keywords: Uveal melanoma; primary tumor; metastasis; treatment; tabentafusp

Medical Science, 2024, 28, e68ms3370

PDF

DOI: https://doi.org/10.54905/disssi.v28i149.e68ms3370

Published: 03 July 2024