Volume 17, Issue 40, 2023

About the Cover

Background: Emerging interest in the development of nanotechnology liposomes to encapsulate, protect and deliver lipophilic components i.e., nutraceuticals, drugs, flavors, antioxidants and antimicrobial agents has revolutionized food, pharmaceuticals, agrochemicals and other industries. Method: Permeation of salicylic acid through a silicon membrane (the model membrane) was examined by using different compositions of buffer and propylene glycol. Franz cells were used to study the penetration of salicylic acid through a silicon membrane. The two buffer solutions of 7.5 and 6.8 pH were prepared. Afterwards, utilizing pH 7.5 buffers, four combinations of concentrations were prepared: 100% buffer, 75% buffer with 25% propylene glycol (3:1), 25% buffer with 75% PG (1:3) and 50% buffer with 50% PG (1:1). Similarly, four different concentrations were prepared with a buffer of 6.8 pH (same as above). Absorption of drugs in the receptor cell medium was investigated by measuring absorbances using a UV/vis spectrophotometer. Result: A total of eight results were obtained and compared to investigate the concentration at which salicylic acid absorbs most effectively.

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RESEARCH

Effect of receptor and donor phase composition on permeation of pharmaceutical compound through model membrane

Muhmmad Abid Mustafa, Mahnoor Rashid, Shakeel Ahmad, Hamza Farooq, Asad Majeed Khan, Saba Naeem, Barira Amin, Fahad Ahmed, Qandeel Rafi, Nurhan Tariq

Background: Emerging interest in the development of nanotechnology liposomes to encapsulate, protect and deliver lipophilic components i.e., nutraceuticals, drugs, flavors, antioxidants and antimicrobial agents has revolutionized food.

Drug Discovery, 2023, 17(40), e27dd1943

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ANALYSIS

Inhibition of New Delhi Metalloβ-lactamase 1 from Klebsiella pneumoniae by an L-aspartic acid derivative

Destiny Morris M, Jhawn Saul G, Sarah Faubion C, Kaliana Lee C, Sung-Kun Kim

The overuse of β-lactam antibiotics has caused drug-resistant bacteria, including NDM-1, a Metallo-β-lactamase that renders inhibitors ineffective. NDM-1 is found in Klebsiella pneumoniae, causing worldwide resistant infections.

Drug Discovery, 2023, 17(40), e28dd1945

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RESEARCH

Alterations in testis histology, reproductive hormones and abnormal sperm morphology in mice treated with polyherbal antimalarials

Rachel Omagha, Emmanuel T Idowu, Chibuisi G Alimba, Adetoro O Otubanjo, Esther O Agbaje, Wellington A Oyibo

Introduction: Malaria remains a significant public health challenge in sub-saharan Africa. As a result, the high cost of conventional antimalarial drugs, poor quality drugs, and the emergence of drug resistance

Drug Discovery, 2023, 17(40), e29dd1947

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Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials

Rachel Omagha, Emmanuel T Idowu, Chibuisi G Alimba, Adetoro O Otubanjo, Esther O Agbaje, Wellington A Oyibo

Introduction: Concerns have been raised in the safety of antimalarial remedies for them to be acceptable for use. The present study is an assessment of safety profiles of two plant-based antimalarial cocktail treatments

Drug Discovery, 2023, 17(40), e30dd1948

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ANALYSIS

Integrative in silico analysis of Pinus Roxburghii phytochemicals for drug discovery

Nayankumar Prajapati, Nikunj Patel

The aim of the present study is to investigate in silico analysis of Pinus Roxburghii plant's photo component for the disease of non-small-cell lung cancer (NSCLC).

Drug Discovery, 2023, 17(40), e31dd1946

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RESEARCH

The protective effects of methylene blue on thioacetamide-induced acute liver and brain injury

Omar ME Abdel-Salam, Eman R Youness, Fatma A Morsy, Amany Ameen Sleem

This study aimed to investigate the potential protective effects of methylene blue (MethyB) on thioacetamide (TAA)-induced acute liver and brain injury in rats.

Drug Discovery, 2023, 17(40), e32dd1951

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ANALYSIS

Anticancer activities of isoflavones from the Millettia thonningii plant and their synthetic derivatives

Owoare RB, Kingsford-Adaboh R, Appiah-Opong R, Nyarko AK, Osei E, Jaato BN, Hayibor KM, Reynisson I, Ayine-Tora DM

Three naturally isolated isoflavones (2, 4 and 5), two synthetically modified isoflavones (3 and 6) and four synthesised isoflavones (10, 12, 13 and 15) were tested in-vitro to access their activities against Chang liver

Drug Discovery, 2023, 17(40), e33dd1952

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Molecular descriptors in quantitative relationship with herbicidal activity of novel derivatives of 6-(5-arylsubstituted- 1-pyrazolyl)-2- picolinic acid

Nidhi Shekhawat, Prithvi Singh

The performed research focused on analyzing the herbicidal properties of several new analogs of 6-(5-aryl-substituted-1-pyrazolyl)-2-picolinic acid using three different methods, namely partial least squares, PLS analysis

Drug Discovery, 2023, 17(40), e34dd1959

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RESEARCH

Nauclea latifolia (smith) remediates the splenic architecture following paracetamol – induced toxicity in male Wistar rats

Ekanem Akpan Udo, Edem Gabriel Donatus, Okon Kingsley Akaninyene, Nwafor Paul, Harrison Imekan

Nauclea latifolia root extract is used for many therapeutic purposes. This work was carried out to assess the effect of Nauclea latifolia root extract on the spleen following paracetamol toxicity in Wistar rats

Drug Discovery, 2023, 17(40), e35dd1956

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Evaluation of Costus afer Ker Gawl. Rhizome fractions for hepatoprotective function and characterization of its bioactive compounds

Blessing N Amadi, Godswill N Anyasor

Objective: To investigate the effect of Costus afer rhizome fraction on liver function, oxidative stress and inflammation biomarkers in diclofenac-induced hepatotoxicity using rat model.

Drug Discovery, 2023, 17(40), e36dd1960

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