Volume 18, Issue 73-74, September - October 2015

About the Cover

Receptor tyrosine kinases (RTKs) are considered as most effective targets for development of anti-cancer therapies. However, most of the RTKs are mutationally altered in cancers which could either develop resistance or differential sensitivities to RTK-targeted therapies signifying role of mutational profiling in cancers. A 60-year old man was presented with 15days persistency of abdominal pain, disturbed bowel habits and rectal bleeding. USG of the abdomen revealed mass (5cmx6cm) in the right hypochondrium (RHC) seemingly arising from colon. Contrast Enhanced Computed Tomography (CECT) confirmed presence of a polyploid mass (4cmx4cm) in the region of hepatic flexure of colon with adherence to liver. Pathological observation of the colonic biopsy diagnosed the patient with stage II CRC and referred for surgical resection of the colonic lesion. Genotyping of the biopsy tissue revealed a major (28bp) deletion in the putative N-terminal tyrosine kinase (TK) domain of VEGFR-1 gene. In silico analysis revealed major structural and energy changes in the mutant protein. This is the first report to document such a major 28bp deletion in TK domain of VEGFR-1/Flt1 in colorectal tumors, the mutants of which are otherwise considered as embryonically lethal.

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ANALYSIS

Evaluation of a new method for Gram staining of bacteria

Bhattacharyya S, Prasad A, Sarfraz A, Jaiswal NK, Kumar R

Gram staining is a very important and useful technique for bacterial identification, often helping in selection of empirical antibiotic therapy.

Medical Science, 2015, 18(73), 16-17

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Prevalence of Oropharyngeal Cancers in Biopsies Received in CIMS, Bilaspur: “A Retrospective-Tertiary Hospital Based Study

Arya RC, Minj MK, Tiwari AK, Bhardwaj AK, Pandey S

This hospital based study which is a tertiary centre seeks to find out the incidence and prevalence of oral and oropharyngeal cancers amongst the patients attending Chhattisgarh Institute of Medical Sciences (CIMS) and undergone for surgery and biopsy.

Medical Science, 2015, 18(73), 18-22

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LETTER

Undergraduate research programs - learning to discovering

Piyusha Kharat

Today’s lifestyle of most students is about studies not pertaining to books and paper but to books and the “Google Search” related to the topic.

Medical Science, 2015, 18(74), 23-24

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CASE REPORT

A Novel 28bp Deletion in Vegfr-1/Flt1 in a 60 yr old patient diagnosed with CRC: a case report

Taseem A. Mokhdomi, Shoiab Bukhari, Asif Amin, Qazi Danish, Asrar H Wafai, Sajad H Wani, Nisar A. Chowdri, Raies A. Qadri

Receptor tyrosine kinases (RTKs) are considered as most effective targets for development of anti-cancer therapies. However, most of the RTKs are mutationally altered in cancers which could either develop resistance or differential sensitivities

Medical Science, 2015, 18(74), 25-29

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