Volume 30, Issue 173, July 2026

D-Allulose, a promising sweetener in the fight against type 2 diabetes - review of recent studies

Aleksandra Rusak-Sobolewska^1♦, Gabriela Krych², Joanna Oklińska², Michał Skóra², Klaudia Jadczak³, Bartłomiej Kazimierski², Weronika Gniado², Dawid Mądry²

¹The Nicolaus Copernicus Municipal Polyclinical Hospital in Olsztyn, ul. Niepodległości 44, 10-045 Olsztyn, Poland
²Provincial Complex Hospital named after Jędrzej Śniadecki in Białystok, ul. M. Curie-Skłodowskiej 26, 15-950 Białystok, Poland
³University Clinical Hospital in Białystok, ul. M. Curie-Skłodowskiej 26, 15-276 Białystok, Poland

^♦Corresponding author
Aleksandra Rusak-Sobolewska, The Nicolaus Copernicus Municipal Polyclinical Hospital in Olsztyn, ul. Niepodległości 44, 10-045 Olsztyn, Poland

ABSTRACT

Diabetes is a common disease associated with high levels of glucose in the body due to poor insulin function or secretion, and it has significant health implications worldwide. Diabetes can be managed through the use of drugs, insulin, and dietary modifications to achieve normoglycemia. D-Allulose is a low-calorie sugar substitute that is showing promise. The current research work discusses the characteristics, metabolism, and effects of D-Allulose on the metabolism of sugars. D-Allulose possesses an impressive ability to induce hypoglycemic action. It has been proven to lower postprandial glucose in patients with diabetes and improve glycemic state for long periods. Moreover, D-Allulose may potentially reduce tissue insulin resistance and decrease the progression of diabetic nephropathy. The ways D-Allulose affects the body are associated with competition of D-Allulose and glucose for their intestinal transporters, inhibition of intestinal enzymes and hormones activation. From a safety standpoint, D-Allulose does not demonstrate adverse events. Despite current technological problems in the production process, further development of bacterial epimerase technology suggests that large-scale production of D-Allulose can become possible in the near future.

Keywords: diabetes mellitus, d-allulose, glycemia, dpsicode

Medical Science, 2026, 30, e136ms3934

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DOI: https://doi.org/10.54905/disssi.v30i173.e136ms3934

Published: 29 July 2026