Volume 30, Issue 167, January 2026

Hybrid therapies in orthopedics: a review of the potential of combining biomaterials and biologic therapies in fracture treatment

Michał Azierski^1♦, Emilia Wiśniewska¹, Alicja Drelichowska¹, Przemysław Ciszewski¹, Paweł Kurzawski¹, Konrad Talarek², Julia Szewczyk², Michał Świta², Anna Szuciak²

¹Student Scientific Association of MedTech at the Center for Remote Learning and Educational Effects Analysis, Faculty of Medical Sciences in Katowice, Silesian Medical University, Katowice, Poland
²Student Scientific Association at the Department of Rehabilitation and Orthopedics, Medical University of Lublin, Lublin, Poland

^♦Corresponding author
Michał Azierski, Student Scientific Association of MedTech at the Center for Remote Learning and Educational Effects Analysis, Faculty of Medical Sciences in Katowice, Silesian Medical University, Katowice, Poland

ABSTRACT

Fracture healing is a complex physiological process, highly sensitive to the precise balance between mechanical stability and biological stimulation. Traditional orthopedic treatments, usually centered on mechanical fixation methods, rarely address such biological deficiencies as impaired vascularization or an insufficient osteogenic activity. In order to improve bone regeneration, this study examines the new idea of hybrid therapies, which combine biomaterials with biologic interventions including stem cells, growth hormones, and gene-based techniques. The integration of mechanical and biological strategies has been shown to accelerate osteogenesis, shorten healing time by up to half compared to conventional methods, and improve the quality and durability of bone repair. Clinical translation is limited to date by immune response challenges, manufacturing complexity, and high costs. Continued development in the areas of biocompatible materials, scalable production techniques, and cost-effective personalization may allow such innovative therapies to become a new standard in fracture management, offering accelerated recovery and enhanced patient outcomes.

Keywords: Hybrid therapy, Biomaterials, Stem cells, Growth factors, Bone healing

Medical Science, 2026, 30, e11ms3739

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DOI: https://doi.org/10.54905/disssi.v30i167.e11ms3739

Published: 25 January 2026