Volume 29, Issue 159, May 2025

Multimodal approach in pain management in pancreatic cancer

Aleksandra Małgorzata Krygowska^1♦, Kamila Sieradocha², Aleksandra Maria Śledziewska³, Aleksandra Zagajewska⁴, Magdalena Cyrkler⁵, Dorota Słupik⁶, Aleksandra Reda⁷, Aleksandra Giba⁸, Michał Wąsik⁹

¹Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
²University Clinical Hospital in Poznań, Przybyszewskiego Str. 49, 60-355 Poznań, Poland
³Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
⁴Infant Jesus Clinical Hospital in Warsaw, Williama Heerleina Lindleya 4, 02-005 Warsaw, Poland
⁵Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
⁶Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
⁷Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
⁸Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland
⁹Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland

^♦Corresponding author
Aleksandra Małgorzata Krygowska, Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland

ABSTRACT

Pancreatic cancer is often associated with significant pain, affecting approximately 75% of patients at the time of diagnosis. This type of pain is frequently the first symptom prompting medical consultation, leading to extended diagnostic pathways and ultimately resulting in delayed detection and poorer prognoses due to the formation of metastases. Managing cancer-related pain by integrating many treatment options, such as pharmacological interventions and interventional procedures, is called a multimodal approach and is being discussed in this article. Healthcare providers should coordinate the aforementioned multimodal approaches to ensure cooperation in the process and the patient’s safety. Furthermore, hope remains in targeted therapies, which focus on the molecular pathways of pain signaling. There is also an opportunity for more personalized strategies that affect the microenvironment of the cancer. Implementing coordinated multimodal pain management strategies should be a caregiver’s priority.

Keywords: pancreatic cancer, pain management, celiac plexus block, analgesia, multimodal therapy

Medical Science, 2025, 29, e66ms3546

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DOI: https://doi.org/10.54905/disssi.v29i158.e66ms3546

Published: 16 May 2025