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Volume 27, Issue 137, July 2023

Beneficial role of Vitamin C on radiation-induced skin cellular injury

Salman Bin Dayel¹, Ali Hassan A. Ali^2,3♦, Mohammed Saad Alqahtani⁴, Saud S Alanazi⁵, Meshari Mahud Alshammari⁵, Faisal Mubarak Almuqbel⁶, Khaled W. Alsaygh⁶, Saud Mohammed Alzahrani⁷, Nasser Hassan Al-swedan⁸, Abdulelah Eyad Alqudaimi⁸, Hamoud M. Almubki⁸, Fahad A. Alzahrani⁸, Tareq A. Althubiti⁹, Wujud Khalid Alanazi¹⁰, Alanoud Abdulqader Ahmad¹¹

¹Department of Dermatology, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSA
²Anatomy Department, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSA
³Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
⁴Internal Medicine Department, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSA
⁵Emergency Department, King Khalid Hospital, Ministry of Health, Al-Kharj, KSA
⁶Internal Medicine Department, King Salman Hospital, Ministry of Health, Riyadh, KSA
⁷Internal Medicine Department, Al Iman General Hospital, Ministry of Health, Riyadh, KSA
⁸College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA
⁹College of Medicine, Vision colleges, Riyadh, KSA
¹⁰College of Medicine, Northern Border University
¹¹Medical Intern, College of Medicine, Qassim University, Unaizah, KSA

^♦Corresponding author
Anatomy Department, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, KSA and Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

ABSTRACT

Maintaining the health of your skin is greatly aided by vitamin C. Along with other supplements, vitamin C extract has been added as a dietary supplement because it can lessen the harmful compounds' tendency to oxidize. In this work, the potential protective effects of vitamin C were investigated in relation to the histological and histochemical alterations in the skin of rats following exposure to gamma radiation. 33 mature male albino rats served as the subjects for the current study. There were three equal groups formed from them. The control group received no medical treatment. Animals in the radiotherapy group were given one dose of gamma radiation. Rats in the third group were administered Vitamin C extract daily at a dose of 20 mg/kg - body weight one week prior to and one week following irradiation. Various stains were used to examine the histopathological and histochemical alterations in skin tissue. Gamma radiation-exposed rats' skin underwent a number of histological and histochemical alterations. Administering vitamin C extract helped to improve these changes. The current study demonstrated Vitamin C's curative and preventive effects on albino rats' skin against radiation-induced skin damage.

Keywords: Vitamin C, Skin injury, Radiation