Volume 27, Issue 135, May 2023

Utility of Hemogram based markers for predicting severity of acute pancreatitis

Kamlesh Taori^1♦, Vijendra Kirnake², Parmeshwar Junare³, Sagar Bothra³, Vishal Padwale¹, Ruchita Kabra⁴, Sourya Acharya⁵, Sunil Kumar⁶

¹Senior Resident, Department of Gastroenterology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
²Professor and HOD, Department of Gastroenterology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
³Assistant Professor, Department of Gastroenterology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
⁴Resident, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
⁵Professor and Head, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
⁶Professor, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India

^♦Corresponding author
Senior Resident, Department of Gastroenterology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Sawangi Meghe, Wardha, India
ORCID: 0000-0002-4055-146X

ABSTRACT

Introduction: Acute pancreatitis is a serious and potentially life-endangering condition. Complete blood count (CBC) is basic laboratory investigation routinely conducted in most of acute pancreatitis patients and by use of simple calculation, CBC based marker could be utilized. Material and methods: Current prospective observational study performed at Medical Gastroenterology Department, JNMC, Wardha, Maharashtra, India during April 2022 to March 2023. After satisfying inclusion and exclusion criteria total 84 acute pancreatitis patients were enrolled and assessed for hemogram based markers and severity indices. Revised Atlanta classification was used for classifying acute pancreatitis severity. AUROC were utilized for calculating cut-off values of hemogram based markers (such as LMR, NLR etc.) APACHE-II score, BISAP score, SIRS and mCTSI for predicting organ failure, ICU admission and outcome. Results: In current study, mean age of patient was 41.1±12.7 years. Based on Revised Atlanta classification, 42.9% patients had mild, 15.5% patients had moderate and 41.7% patients had severe pancreatitis. WBC count, Neutrophils, NLR, PLR, mCTSI, SIRS, BISAP and APACHE II were significantly increasing while Lymphocyte and LMR was significantly decreasing with raising acute pancreatitis severity (p<0.05). By using AUROC NLR (Neutrophil lymphocyte ratio) had significantly predicted ICU admission (0.761; p<0.05) and organ failure (0.797; p<0.05). Conclusion: Evaluating severity based on hemogram based marker were early, easy and simple to calculate compared to complex severity indices which require multiple parameters for calculating severity index for prediction of organ failure, ICU admission conversely, severity indices were better compared to Hemogram based marker for predicting outcome of acute pancreatitis.

Keywords: Acute Pancreatitis, Hemogram based markers, Organ failure, ICU admission

Medical Science, 2023, 27, e219ms2970

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DOI: https://doi.org/10.54905/disssi/v27i135/e219ms2970

Published: 12 May 2023