Volume 27, Issue 135, May 2023

Large duct intrahepatic cholangiocarcinoma arising from intraductal papillary neoplasm of bile duct: A rare case report

Neha A¹, Thanka J^2♦, Rajendran³, Shobana B⁴

¹Postgraduate, Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India
²Professor and Director of Pathology, Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India
³Professor and HOD, Department of Gastro Surgery, Sree Balaji Medical College and Hospital, Chennai, India
⁴Associate Professor, Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India

^♦Corresponding author
Professor and Director of Pathology, Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India
ORCID: 0000 0002 7499 5552

ABSTRACT

Intrahepatic cholangiocarcinoma (iCCA) is one of the primary carcinomas of the bile duct. It is a malignant intrahepatic epithelial neoplasm with biliary differentiation arising in the liver periphery/proximal to the left and right hepatic ducts with greater significance and more clinical and therapeutic challenges. The average age at diagnosis is >50. It presents as three major macroscopic growth patterns (mass-forming (MF), periductal infiltrative (PI) and intraductal growth (IG)). The worrisome mortality of these tumours, which accounts for 2% of all cancer-related fatalities globally each year, is caused by their discrete form, high aggressiveness and resistance to chemotherapy. Histological confirmation is necessary because the non-invasive methods currently used to diagnose cholangiocarcinoma are insufficient. We present a case of large duct intrahepatic cholangiocarcinoma of mass forming type arising from IPNB (intraductal papillary neoplasm of bile duct) with high grade dysplasia in a 60-year-old male.

Keywords: Intrahepatic cholangiocarcinoma, iCCA, Intraductal papillary neoplasm, Bile duct, Intrahepatic epithelial neoplasm

Medical Science, 2023, 27, e216ms2969

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DOI: https://doi.org/10.54905/disssi/v27i135/e216ms2969

Published: 05 May 2023