Volume 27, Issue 133, March 2023

Acute onset psychosis in a patient of tuberous sclerosis: A rare entity

Vaishali Sehgal^1♦, Apoorva Yadav¹, Isha Ahluwalia², Pradeep S Patil³

¹Junior Resident, Department of Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.
²Senior Resident, Department of Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.
³Professor and HOD, Department of Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.

^♦Corresponding author
Vaishali Sehgal, Junior Resident, Department of Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India

ABSTRACT

The Tuberous Sclerosis Complex (TSC) is a multisystem autosomal dominant condition occurring due to mutations in the TSC1 or TSC2 genes affecting around 1 in 20,000 people. TSC is inclusive of tumours of skin, kidney, brain, lung and heart as well as neurological conditions like seizures, autism spectrum disorder and intellectual disability. An array of neuropsychiatric illness known as TSC-associated neuropsychiatric diseases (TAND) are identified in around 90% of people with TSC. Among them, psychosis has been reported only in around 2.3% of cases globally and rarely from India. The Indian data of psychosis in patients of TSC is very sparse. Hereby, we report a case of a 20-year-old male who presented with symptoms of acute psychosis, catatonia and drug induced extrapyramidal symptoms (EPS) and MRI brain showed features suggestive of tuberous sclerosis complex.

Keywords: Tuberous sclerosis complex, Catatonia, Acute psychosis, Adenoma sebaceum, Cortical tubers, Subependymal Giant cell astrocytoma

Medical Science, 2023, 27, e167ms2748

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DOI: https://doi.org/10.54905/disssi/v27i133/e167ms2748

Published: 27 March 2023