Volume 27, Issue 133, March 2023

Atrial fibrillation patient with sleeve gastrectomy had pulmonary embolism even with the usage of apixaban

Osama Abdullah Abdulrahman^1♦, Mohammed Ibrahim Alshinkity¹, Fawaz Saeed Baalaraj¹, Raghad Majed Hariri¹, Abdulhalim S Serafi²

¹Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
²Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

^♦Corresponding author
Faculty of Medicine, Umm Al-Qura University, Makkah Saudi Arabia

ABSTRACT

Our patient is a 48-year-old male known case of atrial fibrillation for 15 years, adherent to his medications, which are apixaban and beta-blocker. He has a history of sleeve gastrectomy two years ago and thereafter, developed a pulmonary embolism. There are studies that revealed that bariatric surgeries had an effect on some medications, especially in absorption. Most of the Direct oral anticoagulants (DOACs) are absorbed in the stomach and proximal intestines. This study demonstrates the possible relation between sleeve gastrectomy and reduced apixaban drug absorption, which can result in a risk of pulmonary embolism and deep vein thrombosis (DVT).

Keywords: Sleeve gastrectomy, atrial fibrillation, embolism, apixaban

Medical Science, 2023, 27, e149ms2885

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DOI: https://doi.org/10.54905/disssi/v27i133/e149ms2885

Published: 15 March 2023