Volume 27, Issue 131, January 2023

Correlation between Kidd blood group (Jk) and renal function tests in the End Stage of Chronic Kidney Disease (ESCKD) patients

Amin Omer Ibrahim Abbas¹, Fath Elrahman Mahdi Hassan Gameel², Mahadi H A Abdulla³, Rabab Hassan Elshaikh⁴, Hisham Ali Waggiallah⁵, Khalid Abdelsamea Mohamedahmed⁶, Ashok Kumar Sah⁷, Asaad M A Babker^8♦

¹Department of Clinical Medicine, Faculty of Medicine, Alrayan Colleges - Saudi Arabia
²Department of Hematology and Immunohematology, College of Medical Laboratory science Sudan University of science and Technology, Khartoum, Sudan
³Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan
⁴Deportment of Hematology, College of Medical Laboratory Sciences, University of Science and Technology, Omdurman, Sudan
⁵Department of Medical Laboratory Science, Prince Sattam Bin Abdul Aziz, Alkharj, Alriyadh, Saudia Arabia
⁶Department of Hematology and Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
⁷Department of Medical Laboratory Technology, School of Health Science, The Neotia University, WB, India
⁸Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates

^♦Corresponding author
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE

ABSTRACT

Background and Objective: Along with erythrocytes, the Kidd glycoprotein exists in the kidney, where it enables the kidney to accumulate an elevated urea concentration, which is required for the kidney to produce concentrated urine. The primary objective of this research is to look for Kidd genes (Jk) in patients with end-stage chronic kidney disease. Materials and Methods: This is a prospective cross-sectional study of 200 patients with chronic renal failure in Khartoum in the period from June 2018 to November 2021. The patients were being monitored in clinic and the majority of them were nearing the end of their chronic kidney disease (ESCKD). Results: When the positive and negative Jk Kidd antigens in ESCKD patients were compared, it was discovered that there were significant differences in urea (P-value 0.001), creatinine (P-value 0.001) and uric acid (P-value 0.04), but no difference in sodium or potassium. Conclusion: Kidd blood group influences serum urea, creatinine and uric acid levels significantly. This effect was observed in different Kidd blood group antigens, including Jka+, Jkb+ and Jka+b+. This means that the Jk group is important in estimating the severity of ESCKD; this discovery could be useful in determining dialysis time and treatment response.

Keywords: Phenotype, Kidd antigens (Jk), renal function test, end stage chronic kidney disease

Medical Science, 2023, 27, e67ms2703

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DOI: https://doi.org/10.54905/disssi/v27i131/e67ms2703

Published: 27 January 2023