Volume 26, Issue 127, September 2022

Evaluation of the normal ratio of fetal brain choroidal plexus size to fetal head size at 11 to 13 weeks of gestation to obtain useful sonographic markers in spina bifida rule out

Tahereh Ghasemi¹, Ayda Roostaee², Zeinab Safarpour Lima², Ladan Younesi Asl^2♦

¹Department of Radiology, School of Medicine, Shahid Akbar-Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
²Shahid Akbarabadi Clinical Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran

^♦Corresponding author
Ladan Younesi Asl, Shahid Akbarabadi Clinical Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran

ABSTRACT

Background: Early detection of open spina bifida (OSB) with ultrasound at 11 to 13 weeks of gestation is considered useful, but no information has been provided on the size and shape of the choroid plexus. Therefore, the aim of this study was to determine the normal ratio of the size of the choroid plexus of the fetal brain to the size of the fetal head at 11 to 13 weeks of gestation to rule out spina bifida. Material and Methods: Aimed to measure cervical transparency (NT: nuchal transparency) during the first trimester of pregnancy and at 11 to 13 weeks of gestation, the pregnant women who has only one fetus were screened and then were checked using E8 or E10 ultrasound machine. Our study was performed during April 2020 to December 2021. Results: The results of our study on 203 embryos are consisting of normal values of crown-rump length (CRL), biparietal diameter (BPD), the length of Choroid plexus (CPL), head area (HA), head circumference (HC), and choroid plexus area (CP-A). Evaluating the ratio of these indicators shows a significant positive correlation between CPA and other indexes include CRL, BPD, HC and HA (p<0.001). Additionally, significant positive correlations between CPL and others include BPD and HC, (p<0.001) and negative correlations between CRL and CPL/OFD and between CRL and CP-A/HA (p<0.05) was seen. Conclusion: With respect to these result it seems that these indicators can be used to distinguish healthy infants.

Keywords: Fetal brain choroidal plexus, Gestation, Sonographic markers, Spina bifida

Medical Science, 2022, 26, ms374e2351

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DOI: https://doi.org/10.54905/disssi/v26i127/ms374e2351

Published: 20 September 2022