Volume 26, Issue 127, September 2022

Biphasic thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and literature review

Moayad Alqazlan¹, Mohammad Anas Dababo¹, Mahmoud Mohammed Bardisi², Abdullah Khaled Almanea³

¹Department of Anatomical Pathology, King Faisal Specialist Hospital and Research Center, Zahrawi St, Al Maather ،Al Maazer, Riyadh 12713, Saudi Arabia
²Department of Pathology and Laboratory Medicine, Riyadh Regional Lab and Blood Bank, Ministry of Health, Saudi Arabia
³Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Saudi Arabia

ABSTRACT

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare tumor type. This tumor closely resembles conventional papillary thyroid carcinoma and exhibits a solid spindle cell component, which is biphasic in appearance. The distinction of this low-grade tumor from other aggressive malignant neoplasms is important for clinical and therapeutic management. Here we present the case of a 19-year-old female who was diagnosed with a biphasic TL-LGNPPA. We also summarize the clinicopathological features, differential diagnosis, and clinical management of TL-LGNPPA with a spindle cell component.

Keywords: Nasopharyngeal cancer, thyroid-like, biphasic, low-grade, spindle, papillary, TTF-1, adenocarcinoma

Medical Science, 2022, 26, ms350e2166

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DOI: https://doi.org/10.54905/disssi/v26i127/ms350e2166

Published: 05 September 2022