Volume 26, Issue 123, May 2022

Evaluation of the effects of intravenous magnesium sulphate on haemodynamic parameters in patients undergoing laproscopic cholecystectomy

Eshana Rasheed^1♦, Anjali Modak², Neeta Verma², Sheetal Madavi³, Nikhil Bhalerao⁴

¹Junior Resident, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, India
²Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, India
³Associate Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, India
⁴Assistant Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, India

^♦Corresponding author
Junior Resident, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, India;

ABSTRACT

Background: Within a decade since the first case of laparoscopic cholecystectomy was performed, it had become the gold standard for managing acute cholecystitis. However, laparoscopy has disadvantages of its own, mostly, secondary to the creation of pneumoperitoneum. Aim: To evaluate (and compare with Normal Saline) the effectiveness of intravenous Magnesium Sulphate (0.5mg/kg) on the haemodynamic parameters among patients undergoing laparoscopic cholecystectomy. Material and methods: This was a single centre, double-blinded, 1:1, parallel, placebo-controlled randomised control trial comparing magnesium sulphate (0.5mg/kg) and normal saline among a total of 40 participants. The duration of surgery, level of sedation, heart rate, and systolicand diastolic blood pressure among the participants were measured. Results: The mean, median and the range of ‘duration of laparoscopy’ in the intervention and the control group were almost equal. The median sedation score was lower in the magnesium sulphate group in comparison to the normal saline group. The mean heart rate in the magnesium sulphate group was lower than the control group and this difference was statistically significant. The SBP increased in both groups following pneumoperitoneum, however, the maximum increase in SBP among participants given MgSO4 was 10%. Comparatively, in the normal saline group, the maximum increase in SBP was 16 %. No participants in either the intervention or the control group had an episode of arrhythmia, bradycardia, or hypotension in either group. Conclusion: Magnesium sulphate reduced the intensity of changes in haemodynamic parameters in comparison to normal saline during pneumoperitoneum.

Keywords: Magnesium Sulphate, Laparoscopy, Cholecystectomy

Medical Science, 2022, 26, ms183e2236

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DOI: https://doi.org/10.54905/disssi/v26i123/ms183e2236

Published: 20 May 2022