Volume 26, Issue 123, May 2022

Evaluation of infection and immunity in children of mothers with HBS antigen

Manijeh Jozpanahi¹, Zahra Hatami², Samira Akbarieh³, Pegah Saeed², Nooshin Jalili^4♦

¹Department of Infectious Disease, Zanjan University of Medical Sciences, Zanjan, Iran
²MD, Zanjan University of Medical Sciences, Zanjan, Iran
³Department of Infectious Disease, Ardabil University of Medical Sciences, Ardabil, Iran
⁴Pulmonologist, Department of Internal Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

^♦Corresponding author
Nooshin Jalili, Pulmonologist, Department of Internal Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

ABSTRACT

Introduction: One of the main chronic diseases in developing countries is Hepatitis B, which is of particular importance due to the underlying cirrhosis of the liver and hepatocellular carcinoma. Therefore, this study was conducted to evaluate the incidence and immunity of children of mothers with hepatitis B. Material and Methods: The present study as a cross-sectional one was performed on HBsAg positive mothers referred to Suhrawardi Infectious Diseases Clinic in Zanjan, Iran, February 2008 to September 2020, during 12 years. In our study 129 medical records of HBsAg-positive mothers referred to the Infectious Diseases Clinic were reviewed and the extent of infection and immunity of their children were analyzed according to various factors such as maternal age, maternal gravid A, and mother HbeAg, as well as receiving or not receiving vaccine and neonatal immunoglobulin. Results: Achieved data from the present study revealed that 76.1% of the offspring of mothers with hepatitis B had a level of protective antibody above 10 international units. Furthermore, 94.1% of vaccine recipients with HbeAg-negative mothers showed a level of protective antibody at least above 10 international units. In children of mothers with HbeAg positive, this rate was 42.9%. In both offspring of both HbeAg positive and negative mothers, the response rate in both vaccine and immunoglobulin recipients were 100% (positive). Conclusion: Among vaccine recipients alone, 94.1% and 42.9% of offspring of HBeAg-negative and -positive mothers were immune. While both vaccine and immunoglobulin recipients had 100% immunity in both groups

Keywords: Antigen, Hepatitis B, Mother

Medical Science, 2022, 26, ms173e2095

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DOI: https://doi.org/10.54905/disssi/v26i123/ms173e2095

Published: 15 May 2022