Volume 26, Issue 122, April 2022

Protective effect of green tea in methotrexate-induced nephrotoxicity

Ali Hassan A Ali^1,2♦, Nasser Awadh W Almutairi³, Faisal Mohammed Al Dawsari³, Abdullah buqaysh S Alshabani⁴, Yousef Saad Almutairi⁴, Meshal Tami Alotaibi⁴, Musab Khalid Alotaibi⁴, Nasser Salman ALSaloom⁴, Mohammad Fahad Alajmi⁴, Abdulaziz Ali Al Talib⁴

¹Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA
²Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
³King Khalid Hospital and Prince Sultan Center for Health Services, KSA
⁴College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA

^♦Corresponding author
Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA; Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

ABSTRACT

Green tea consumption is associated with reduced disease prevalence, and degenerative disorders. Subsequently, green tea has been included as a dietary supplement with other nutritional and vitamin supplements. Our study aimed to evaluate the effect of methotrexate administration on the kidneys and the role of green tea in its protection. It was performed on twenty-one albino rats. The animals were distributed into three equal groups. Control group, Methotrexate group and Methotrexate-green tea group whose rats were injected with methotrexate and green tea for nine weeks. Renal functions, histopathological as well as immunohistochemical changes were evaluated at the end of the study. Increased Blood urea nitrogen, Uric acid and Creatinine serum levels and marked changes in kidney architecture were obvious in the second group. These changes were in the form of glomerulosclerosis, tubular cell necrosis hemorrhages as well as inflammatory infiltrations. There was a relatively return to the normal structure of kidney structure in the group treated with Green tea plus Methotrexate.

Keywords: Green tea, Methotrexate, Nephrotoxicity, Oxidative stress

Medical Science, 2022, 26, ms126e2200

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DOI: https://doi.org/10.54905/disssi/v26i122/ms126e2200

Published: 09 April 2022