Volume 26, Issue 122, April 2022

A comparative study of postoperative analgesia and safety of intravenous nalbuphine versus intravenous tramadol in patients undergoing lower abdominal surgeries

Shiras P¹, Sanjot Ninave², Aruna Chandak³, Amol Bele⁴, Nikhil Bhalerao⁵, Shuguftha Sherin⁶

¹Junior resident 3rd year, Department of Anesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Maharashtra, India
²Professor, Department of Anesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Maharashtra, India
³Professor, Department of Anesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Maharashtra, India
⁴Assistant Professor, Department of Anesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Maharashtra, India
⁵Assistant Professor, Department of Anesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Maharashtra, India
⁶Junior resident 1st year, Department of Obstetrics and Gynecology, Government Medical College Kannur, Kerala, India

ABSTRACT

Introduction: Providing excellent pain relief is one of the primary priorities in postoperative care. Nalbuphine is an opioid analgesic that works as both an agonist and an antagonist and has a superior safety profile and fewer adverse effects than other opioids. Tramadol acts on opioid receptors and inhibits neuronal uptake of norepinephrine and serotonin. Aims and objectives: To compare intravenous inj. Nalbuphine (0.1mg/kg) with intravenous inj. Tramadol (1mg/kg) in terms of duration of post-operative analgesia, sedation and any adverse effects. Methodology: Two equal groups of 30 participants each were selected randomly from 60 female patient posted for lower abdominal gynecological surgeries - Group N and Group T. The Group N candidates were administered with inj nalbuphine 0.1mg/kg IV and those in the group T were administered with inj tramadol 1mg/kg IV when they complained of pain post operatively, VAS >3 and rescue dose was repeated whenever the VAS score was >3. We compared the postoperative analgesia in both the groups along with sedation and adverse effects. Results: Group N showed lower VAS scores and better sedation scores than Group T. The duration of analgesia was longer in group N when compared to group T. Group N patients had comparatively less side effects than Group T patients. Conclusion: Nalbuphine at the dose of 0.1mg/kg not only had a better analgesic effect than tramadol 1 mg/kg, but also a more sedative effect with fewer adverse effects when given intravenously.

Keywords: Nalbuphine, Tramadol, Postoperative analgesia, lower abdominal surgeries

Medical Science, 2022, 26, ms116e2176

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DOI: https://doi.org/10.54905/disssi/v26i122/ms116e2176

Published: 03 April 2022