Volume 26, Issue 121, March 2022

Anti-ulcer effects of chamomile, sesame and flax oils on gastric ulcer-induced rat model

Nahla S Zidan^1,2

¹Department of Nutrition and Food Science, University of Tabuk P.O. Box 699, Tabuk 71491, Saudi Arabia
²Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt

ABSTRACT

This study looked at the gastroprotective effects of chamomile, sesame, and flax oil extracts on experimental rats with piroxicam-induced stomach ulcers. In this investigation, 36 albino rats weighing 100-10 g were separated into 6 groups, one of which was preserved as a control –ve group, while the other five were given one oral dose of 2ml oil every day for the duration of the experiment. First group was kept as a (+ve) control group, while the others were given orally administered oils (2 ml per rat each day) for four weeks. Feed intake, body weight gain percent and feed efficiency ratio were all part of the biological examination. The levels of glutathione and malondialdehyde in the stomach were determined. The Histopathological changes in stomach tissues were also looked into. The use of oils, according to the research, enhanced all previous criteria. Histological investigation confirmed the biochemical results. The best treatments were found to occur with high doses. Oils considered as a prophylactic measure against stomach ulcers induced by non-steroidal anti-inflammatory drugs, according to the study (NSAIDs).

Keywords: Natural oils, antioxidants, peptic ulcer

Medical Science, 2022, 26, ms98e2035

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DOI: https://doi.org/10.54905/disssi/v26i121/ms98e2035

Published: 11 March 2022