Volume 25, Issue 115, September 2021

Dynamics of respiratory ventilation function indices in patients with chronic obstructive pulmonary disease and bronchial asthma with comorbid irritable bowel syndrome

Svitlana Novychenko^♦, Svitlana Kovalenko, Natalia Lytvyniuk, Elvira Yasynska, Olga Skrynchuk, Stanislav Roborchuk, Tetiana Shchudrova, Tetiana Unguryan

Bukovinian State Medical University, Chernivtsi, Ukraine

^♦Corresponding author
Bukovinian State Medical University, Chernivtsi, Ukraine

ABSTRACT

The article presents the study of the respiratory function in patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) with comorbid irritable bowel syndrome (IBS). We studied the ventilation function of external respiration (FER) and the nature of its changes in response to bronchodilator in COPD and BA with comorbid IBS patients. In patients with COPD, there was a decrease in both FEV1 and FVC. The degree of spirometric disorders correlated with the severity of the disease. The obstructive type of graphic image of the curve "flow-volume", which was characterized by a decrease in the volume velocity of the airflow, was observed in all patients. The ratios of FEV1/FVC % and MEF 25%-75% were reduced in all patients with COPD. The comorbid IBS in patients with moderate BA makes it impossible to achieve complete control over the course of BA due to the persistent spasm of the peripheral bronchi, which requires increased inhalation therapy. Based on the results, in patients with COPD and IBS, the predominance of the peripheral type of persistent generalized bronchial obstruction was revealed. Transient generalized obstruction syndrome prevailed in patients with BA and IBS, completely reversible obstruction – in BA patients without IBS, and maintenance of the peripheral bronchi spasm in BA patients with IBS.

Keywords: bronchial asthma, chronic obstructive pulmonary disease, irritable bowel syndrome, respiratory function

Medical Science, 2021, 25(115), 2145-2151

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