Volume 25, Issue 114, August 2021

Unusual presentation of lupus erythematous profundus in a young female treated by intralesional trimacinolone and oral methotrexate: A case report

Awadh Alamri¹, Sahal Samarkandy¹, Hatim Al-Maghraby⁴, Hassan Huwait⁴, Samir Alamri², Hebah Alahwal², Mazen Dajam^3♦

¹Dermatology Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, King Abdulaziz Medical City, Jeddah, Saudi Arabia
²Dermatology Department, King Abdulaziz Medical City, Jeddah, Saudi Arabia
³College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
⁴Pathology Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, King Abdulaziz Medical City, Jeddah, Saudi Arabia

^♦Corresponding author
Mazen Dajam; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

ABSTRACT

Systemic lupus erythematosus is a chronic autoimmune condition that can attack almost any organ. In fact, its clinical manifestations and serological abnormalities are the most diverse one among other autoimmune diseases. An uncommon distinctive entity of this disease is lupus erythematosus profundus. Herein, we report a case of 14 years old female complained of a progressive lesion over her right arm that was ulcerated later. Lupus erythematosus profundus diagnosis was confirmed through multiple histopathological examination. Patient was started on hydroxychloroquine 200 mg twice daily, but she could not tolerate it. Accordingly, she was switched to methotrexate in addition to trimacinolone injection, as she showed more tolerance and improvement. The patient was seen for almost two years.

Keywords: Systemic lupus erythematosus, lupus erythematosus profundus, trimacinolone injection, oral Methotrexate.

Medical Science, 2021, 25(114), 2043-2047

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