Medical Science
Volume 25, Issue 113, July 2021
Prevalence of abnormal pulmonary functions in Parkinson’s disease and its correlation to the disease severity and quality of life
Mohammed Elsherif1♦, Asem Abdelhamid Hewidy2, Tamer Elhadidy2, Ahmed Esmael1, Mohamed Elsayed Flifel1
1Department of Neurology, Faculty of Medicine, Mansoura University,
Mansoura, Egypt
2Department of Chest Medicine, Faculty of Medicine, Mansoura
University, Mansoura, Egypt
♦Corresponding author
Department of Neurology, Faculty of Medicine, Mansoura University,
Mansoura, Egypt
ABSTRACT
Purpose: To know the effects of Parkinson’s disease (PD) on pulmonary function parameters and the extent of this on the severity of the disease and quality of life to give more understanding of the nature of the disease and its effects. Methods: The study conducted at the neurology and chest departments of Mansoura university hospital, Egypt. The PD patients were subjected to pulmonary function tests, measurements for the strength of the respiratory muscles with their correlation with scales for quality of life (QOL) in PD and motor function. PD divided into 2 groups’ normal pulmonary function (NPF) and abnormal pulmonary function (APF). Results: Fifty-two participants and the most common causes for APF (n =16) were restrictive (43.75%) and obstructive (25%). The APF patients showed a lower FEV1/FVC, FEV1and MEF50 and a high correlation with UPDRS total, modified H&Y, and S&E ADL. FEV1, FVC, PEF, and FEF25-75% showed a significant inverse correlation with bradykinesia. There was a significant inverse correlation between rigidity and these specific parameters FVC and PEF. MEP, FEF25-75%, and PEF associated with significant inverse correlations and UPDRS-III scores. Mobility domain scores correlated inversely with certain pulmonary functions MEP, FVC, PEF, and FEV1. Conclusion: There is an impairment of certain pulmonary function tests and respiratory muscles power in PD patients. Rigidity and bradykinesia showed the strongest association with the deterioration of those variables. All these abnormalities alter the quality of the daily activities of PD patients.
Keywords: Pulmonary function tests; Parkinson’s disease; respiratory
dysfunction; quality of life.
Medical Science, 2021, 25(113), 1739-1747
