Medical Science
Volume 25, Issue 111, May, 2021
Protective role of TD0014 against sodium valproate-induced reproductive toxicity in male wistar rats
Tran Thai Ha1, Pham Thi Van Anh2, Pham Ba Tuyen3♦, Mai Phuong Thanh2, Nguyen Thi Huong Lien4, Pham Quoc Binh5, Pham Thuy Phuong5, Đoan Quang Huy5, Tran Thi Minh Tam5, Nguyen Thi Bach Tuyet5, Nguyen Quoc Huy5, Dinh Thi Hong Minh5
1National Hospital of Traditional Medicine, Ha Noi, Vietnam
2Hanoi Medical University, Ha Noi, Vietnam
3Traditional medicine Ministry of public security, Ha Noi, Vietnam
4Sunstar Joint Stock Company, Ha Noi, Vietnam
5Vietnam University of Traditional Medicine, Ha Noi, Vietnam
♦Corresponding author
Traditional medicine Ministry of public security, Ha Noi,
Vietnam
ABSTRACT
Sodium valproate (VPA), a common treatment of epilepsy and other diseases, is known to have severe toxic effects on testis both in experimental animals and in humans. This study was carried out to assess the protective activities of the TD0014 against sodium valproate (SVP)-induced reproductive toxicity in male rats. Animals were treated with TD0014 at the dose of 1.8 g/kg/day and 5.4 g/kg/day, and co-administered with SVP (500 mg/kg) for 7 weeks before all reproductive parameters were determined. The results showed all doses of TD0014 significantly protected the decrease testicular weight and testosterone level in SVP rats. TD0014 significantly improved the decrease sperm count and sperm motility in SVP treated rats. Moreover, testicular histology of TD0014 + SVP groups showed declining of testicular histopathologies as compared to SVP group. Therefore, it seems that TD0014 can prevent testicular and spermatozoal damage in male rats induced with SVP. The higher protective effect was seen with TD0014 at 5.4 g/kg dose.
Keywords: TD0014, sodium valproate, male rat
Medical Science, 2021, 25(111), 1241-1247
