Background: The inappropriate use of analgesics can have implications on health and can also have effect on quality of life. This
inappropriate use can lead to misusing healthcare resources and increasing healthcare costs. Objective: To determine the prevalence
of analgesic misuse, pattern and side effects of analgesics among adults aged 15 -65 years attending general clinics in Al-Zaher
primary health care center (PHCC) in Makkah. Subjects and methods: A cross-sectional study was conducted in Makkah at Alzaher
PHCC enrolling 214 patients of age 15-65 years attending general clinics from August - September 2019. A systematic random
sample technique was adopted to recruit adult patients attending clinics. A self-administered validated questionnaire was used for
data collection including sociodemographic data, the pattern of analgesics use, and awareness about the analgesics use and its side
effects. Results: The study included 214 participants. The mean age of our study participant was 37 ± 11.9 years. The prevalence of
analgesics use was 94.9%. More than half of the participants who used analgesics (58.4%) claimed that these analgesics were not
prescribed. The most frequently used analgesic was paracetamol (64.5%). The most frequent indications for using analgesics among
the participants were headache (34.5%), joint pain (22.7%), and fever (11.8%). The prevalence of analgesics misuse among the
participants was 26.6%. Most of the participants (73.4%) were aware of the analgesics misuse side effects. The most frequently
known side effects were hepatotoxicity (39.3%) and nephrotoxicity (30.8%). Conclusion: The use of analgesics among the adult
population in Makkah, particularly for headache is alarming. Misuse of analgesics is also higher that needs immediate attention.
Awareness regarding analgesics side effects is high; however, for particular side effects, it is suboptimal.
Keywords: analgesic misuse, pattern, prevalence, primary health care Centre, Saudi Arabia