Volume 24, Issue 105, September - October, 2020

Changes in blood and inner organs of immunodeficient rats induced by complex of natural peptides and proteins with immunostimulating activity

Elena Kotenkova, Ekaterina Vasilevskaya^♦, Ekaterina Barysheva, Irina Chernukha, Andrey Lisitsyn

The V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation

^♦Corresponding author
The V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation; Email: e.vasilevskaya@fncps.ru

ABSTRACT

The results of complex extract (Sus Scrofa thymus, spleen and lymph nodes) and its fractions (molecular weight: <5 kDa; 5-30 kDa; > 30 kDa) study on alterations in morphology, blood biochemical status, and antioxidant capacity of Wistar rats with cyclophosphamide immunodeficiency model are present in this article. The significant difference noted in fractions <5 kDa and fractions >30 kDa that was a minimal tendency to recovery after immunosuppression. Thus, positive effect was in fraction 5-30 kDa, it was revealed protein metabolism normalization leads to stable increase in rat weight, main renal stabilization background and hepatic markers, corresponding to decrease in pathological changes in liver and kidneys. Also it was detected significant increase in antioxidant blood serum activity and decrease in signal amplification in ESR spectroscopy. Further investigation advisability of immune pig organs extracts fraction will be devoted to fraction 5-30 kDa, which demonstrated maximum therapeutic effect.

Keywords: DDW, deuterium, immune system, biochemistry, antioxidant capacity

Medical Science, 2020, 24(105), 3655-3663

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