Medical Science
Volume 24, Issue 104, July - August, 2020
Efficacy of eradication therapy in children with H. pylori-associated diseases depending on levels of nitric oxide and vitamin D
Tаmila Sorokman1♦, Nadiia Chernei1, Snezhana Sokolnyk1, Iryna Sokolnyk1, Nataliya Popelyuk2, Leonid Shvygar1
1Department of Pediatrics and Medical Genetics of Bukovinian State Medical University, Teatralna sq., 2, Chernivtsi, 58002, Ukraine
2Department of Pediatrics, Neonatology and Perinatal Medicine of Bukovinian State Medical University, Teatralna sq., 2, Chernivtsi,
58002, Ukraine
♦Corresponding author
Department of Pediatrics and Medical Genetics of Bukovinian State Medical University, Teatralna sq., 2, Chernivtsi, 58002,
Ukraine; Email: t.sorokmam@gmail.com
ABSTRACT
Introduction: Nitric oxide (NO) and vitamin D (25(OH)D3) plays a crucial role in many physiological processes in the human body.
Aim: To investigate the effect of 25(OH)D3 and NO on the efficacy of eradication therapy in children with H. pylori-associated
diseases. Methods: An observational prospective cohort study of 128 children with H. pylori-associated disease (endoscopic
examination with verification of H. pylori in mucosal biopsies during primary endoscopy and 4-6 weeks after the end of treatment,
the presence of the antigen CagA H. pylori in feces, levels 25(OH)D3) and NO). Results: The average of 25(OH)D3 was 25.7 ± 1.4
ng/mL, with H. pylori (+) - 1,6 times lower. In the group of children with vitamin 25(OH)D <20 ng/ml level, the eradication rate of H.
pylori infection was 68,3%, while in the group of children with vitamin 25(OH)D>20 ng/ml – 84,6 %. The NO level in the blood
plasma of the children was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol / l. Conclusion: Vitamin D and NO deficiency is
associated with worse rates of H. pylori eradication during treatment.
Keywords: H. pylori infection, Vitamin D, Nitric oxide.
Medical Science, 2020, 24(104), 1895-1903
