Volume 24, Issue 103, May - June, 2020

Clinico-pathological characterization of colonic cancer among patients attending KFH Hospital at Albaha, Saudi Arabia

Thamer Alghamdi^1♦, Abukhelaif A.E.E², Hala A.Khalafalla³, Jiehan M. Hassan⁴, Ihab Shafek Atta⁵

¹Assistant professor and Consultant of General and Visceral Surgery, Department of General Surgery, Faculty of Medicine, Albaha University, KSA
²Department of Pathology, Faculty of Medicine, Albaha University, KSA
³Faculty of Medicine, Female Section Albaha University, KSA, Faculty of Medicine, Omdurman Islamic University, Sudan
⁴Faculty of Medicine, Female Section Albaha University, KSA, Faculty of Medicine, University of Khartoum, Sudan
⁵Department of Pathology, Faculty of Medicine, Albaha University, KSA, and Faculty of Medicine, Al-Azhar University, Assuit, Egypt

^♦Corresponding author
Assistant professor and Consultant of General and Visceral Surgery, Department of General Surgery, Faculty of Medicine, Albaha University, KSA

ABSTRACT

Colorectal cancer (CRC) is considered as the third most frequent cancer worldwide and ranks as the fourth leading cause of death from cancer. The aims of this study were to analyze the epidemiologic and histopathologic characteristics of colorectal cancer among patients attending King Fahad Hospital at Albaha province, Saudi Arabia. Patient and method: a retrospective study was done over a period of 5 years from 2014 to 2018, the reported data on colonic endoscopic biopsies and surgical colectomy were retrieved and analyzed against sex of patients, duration and presentation of the disease, the histopathological characteristics of the tumor such as tumor differentiation and staging. Results: The data revealed a general increase in CRC incidence in both sexes with a slight preponderance of males (31; 53%) over females (27; 47%). The mean age at the time of diagnosis was 58 years (57 in females and 59 in males), with the majority of patients being older than 49 years (n = 44; 77 %). There was a slight predominance of cases among males (n=30; 51.7%). Site of occurrence was found that 39.7% (n=23) of tumors arose from the sigmoid colon, those developing from recto-sigmoid, ascending and descending colon constitute (17; 29.3%), (10; 17.2% and (8; 13.8%) of cases respectively. The endoscopic findings among study cases showed that most of the tumors were fungating nodular mass with the ulcerative surface. Regarding histopathological grading, more than half of adenocarcinomas were moderately differentiated adenocarcinoma in 32 (55.2%), 19(32.7%) were well-differentiated and only 7(12.1%) were poorly differentiated carcinoma. Conclusion: Our analysis of daily clinical practice provided valuable information as all consecutive patients of a secondary-care governmental hospital were included. The future needs of this demographic variation must be anticipated. Greater awareness of the potential for CRC in young people must be emphasized to all physicians.

Keywords: abdominal pain, adenocarcinma, Colerectal cancer, histological grading, rectal bleeding

Medical Science, 2020, 24(103), 1572-1577

PDF