Volume 24, Issue 103, May - June, 2020

Side effects of glucocorticoids in treatment of patients with musculoskeletal conditions

Quang-Tri Lê^1♦, Ngoc- Thanh Do², Huu- Hung Phan³, Minh-Hoang Nguyen⁴

¹Department of Orthopedics, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, Ho Chi Minh City, 72706, Viet Nam; Email: lqtri@ntt.edu.vn; tsbstri@yahoo.com; https://orcid.org/0000-0002-2777-0828
²Department of Orthopedics, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, Ho Chi Minh City, 72706, Viet Nam; Email: bs.dongocthanh@gmail.com
³Department of Orthopedics, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, Ho Chi Minh City, 72706, Viet Nam; Email: bsphhung@gmail.com
⁴Department of Orthopedics, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, Ho Chi Minh City, 72706, Viet Nam; Email: nthoang@ntt.edu.vn; bsnguyenminhhoang@yahoo.com.vn; https://orcid.org/0000-0002-5021-669X

^♦Corresponding author
Department of Orthopedics, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, Ho Chi Minh City, 72706, Viet Nam; Email: lqtri@ntt.edu.vn; tsbstri@yahoo.com

ABSTRACT

Aims: This study investigated the complication rates in patients with musculoskeletal conditions treated with glucocorticoid and the relationship between glucocorticoid and complications. Material and methods: This study employed a cross-sectional and descriptive approach to 189 patients with musculoskeletal conditions treated with glucocorticoid. Results: Patients treated with glucocorticoid had high rates of complications such as hypertension (25.9%); hyperglycemia (24.9%); gastrointestinal conditions (36.0%). Patients treated with dexamethasone had higher complication rates than patients treated with pred and methylpred, such as Cushing syndrome (31.3%, in comparison with 10.8% in the other group), hyperglycemia (45.2% – 19.0%), gastrointestinal conditions (59.5% – 29.3%), adrenal failure (11.9% – 1.4%) (p< 0.05). Conclusion: Patients with musculoskeletal conditions treated with glucocorticoid suffered from high complication rates which were related to types of used glucocorticoid.

Keywords: musculoskeletal conditions, glucocorticoid, side effects

Medical Science, 2020, 24(103), 1566-1571

PDF