Volume 24, Issue 103, May - June, 2020

Non Alcoholic Fatty Liver Disease (NAFLD) in Metabolic Syndrome (MetS)- A case control study

Julie Ann Thomas¹, Sourya Acharya^2♦, Samarth Shukla³, Joel Joy Thomas⁴, Sree Karthik Pratapa⁴, Vidyashree Hulkoti⁴

¹Undergraduate Student, Datta Meghe Institute of Medical Sciences (Deemed to be University), Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra, India
²Professor, Dept. of Medicine, Datta Meghe Institute of Medical Sciences (Deemed to be University), Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra, India
³Professor, Dept. of Pathology, Datta Meghe Institute of Medical Sciences (Deemed to be University), Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra, India
⁴Resident, Dept. of Medicine, Datta Meghe Institute of Medical Sciences (Deemed to be University), Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra, India

^♦Corresponding author
Professor, Dept. of Medicine, Datta Meghe Institute of Medical Sciences (Deemed to be University), Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra, India; Email: souryaacharya74@gmail.com

ABSTRACT

Aim: To study the proportion/frequency of non alcoholic fatty liver disease (NAFLD) in Metabolic Syndrome (MetS) versus individuals without metabolic syndrome and to establish an association between NAFLD and Metabolic syndrome. Methods: This case control study consisted of 200 participants- 100 with metabolic syndrome and 100 without metabolic syndrome fulfilling the inclusion and exclusion criteria was conducted in Acharya Vinoba Bhave rural tertiary care Hospital in central India. Anthropometric measurements including height, weight, waist circumference and BMI were recorded. The blood pressure was also measured by standard methods. Ultrasonography was performed on subjects to detect NAFLD. Results: Mean age of the study subjects in metabolic syndrome group and non-metabolic syndrome group were 44.69±15.15 and 37±12.79 respectively with a slight male preponderance. Eighty-six (86%) of the individuals with metabolic syndrome and 34% of the ones without metabolic syndrome were obese with BMI  25 Kg/m2. Mean triglyceride levels were higher. The overall frequency of NAFLD was 67% in metabolic syndrome group and 12% in non-metabolic syndrome group, which is statistically significant (p=0.0001). Conclusion: The overall frequency of NAFLD in metabolic syndrome was 67%.This was significantly higher than the incidence rates in the non-metabolic syndrome group. Ultrasonography evidence of NAFLD in cases of obesity and or MetS should increase the awareness of primary preventive and or therapeutic measures.

Keywords: NAFLD, MetS, Triglyceride, anthropometry, obesity

Medical Science, 2020, 24(103), 1490-1499

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