Volume 24, Issue 103, May - June, 2020

Efficacy of red cabbage (Brassica oleracea) leaves extract in protecting gastric ulcer induced by Naproxen in male rats

Afnan H Saaty

Food and Nutrition Dept., Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, KSA

ABSTRACT

Gastric ulcer disease refers to painful sores or ulcers in the lining of the stomach. This research was planned to determine the possible gastro-protective effects of red cabbage (RC) leaves extract against naproxen (NX)-induced gastric mucosal damage in experimental rats. Rats (n=50) were distributed into 5 groups; control, NX, RC leaves extract (1g/kg) +NX, amlodipine (AD) (0.5 mg/kg) (reference drug) +NX and RC+AD+NX daily for 14 days. Rats were sacrificed 6 hours post NX given. Blood samples and gastric tissue were collected for biochemical analysis and histopathological examination. Results showed that there were significant decline in ulcer index and gastric acidity, with significant increase on pH level in pre-treated groups compared with NX group. Pretreatment with RC, AD and their combinations significantly reduced gastric oxidative stress (MDA) and serum pro-inflammatory cytokines with significant increases in the activity of gastric antioxidant enzymes (SOD) and mucin content compared with NX treated rats. The group of rats received RC+AD+NX showed a better protective ability compared with other groups. These results confirm that RC leaves extract has a potent gastro protective activity on NX induced gastric ulcer, which could be explained by its effect as an anti-inflammatory and antioxidant agent.

Keywords: Gastric ulcer,red cabbage leaves extract, antioxidant, anti-inflammatory.

Medical Science, 2020, 24(103), 1480-1489

PDF