Volume 24, Issue 103, May - June, 2020

Clinical peculiarities of the course of bronchial asthma with debut at different age

Olena Koloskova¹, Natalia Shevchenko¹, Uliana Marusyk^1♦, Maryana Grytsiuk², Valentyna Bebykh³

¹Department of Pediatrics and Children Infectious Diseases, Higher State Educational Establishment of Ukraine, Bukovinian State Medical University, Chernivtsi, Ukraine
²Department of Social Medicine and Public Health, Higher State Educational Establishment of Ukraine, Bukovinian State Medical University, Chernivtsi, Ukraine
³Department of foreign languages, Higher State Educational Establishment of Ukraine, Bukovinian State Medical University, Chernivtsi, Ukraine

^♦Corresponding author
Department of Pediatrics and Children Infectious Diseases, Higher State Educational Establishment of Ukraine, Bukovinian State Medical University, Chernivtsi, Ukraine; Email: marusyk.uliana@bsmu.edu.ua

ABSTRACT

The objective was to study the clinical features of the course of the disease with the debut at different ages of childhood in order to improve the treatment and prevention measures for children with bronchial asthma. The study was conducted in the design of longitudinal monitoring of child cohorts formed by simple random sampling, the duration of which was 10 years. Deviations in the severity of the course of the disease, the control of BA symptoms, the number of exacerbations and hospitalizations due to a severe attack of bronchial obstruction, and the duration of inpatient treatment were evaluated. The research included 195 children of all ages suffering from asthma with different disease debuts. At the initial examination the family-genealogical burden index for atopic diseases in the comparison groups did not differ significantly and amounted to 0.15 ± 0.01 c.u. in group I, and 0.17 ± 0.01 cu in group II and in group III - 0.14 ± 0.008 c.u. According to the GINA criteria, the control of BA symptoms was achieved best of all in patients with an early-onset asthma phenotype, and the worst in patients from clinical group II. The study showed that the phenotype of early-onset asthma is characterized by a tendency to atopy according to the father’s pedigree. The debut of bronchial asthma in preschool age is characterized by a high frequency of burden of the maternal pedigree with allergic diseases. The characteristic features of the phenotype of late-onset asthma are the least burden of a family allergic history.

Keywords: Bronchial asthma, early-onset asthma, late-onset asthma, pedigree, comorbidity

Medical Science, 2020, 24(103), 1385-1391

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