Volume 24, Issue 103, May - June, 2020

Expression of CD3 and CD34 Markers in OSCC

Babak Karimi¹, Mahsa Saidian^2♦, Ali Rohani², Parisa Boostanifard², Somayeh Dahanzadeh², Parisa Sarikhani³

¹Assistant professor, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
²Dentist, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³Pediatric Dentistry Resident, Department of Pediatric Dentistry, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

^♦Corresponding author
Mahsa Saidian, Dentist, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

ABSTRACT

Background and Objective: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy transpires in the oral cavity. The aim of the present study was to examine the expression of CD34 marker (hematopoietic stem cell) and CD3 (T-cell marker) in OSCC using immunohistochemical analysis. Materials and methods: Immunohistochemical staining was performed on 15 paraffinembedded OSCC samples with anti CD3 and CD34 markers antibodies. The peritumoral and intratumoral hot spot areas were selected separately for lymphatic density and blood vessel counting. Data were analysed using t-test, ANOVA, and SPSS ver 19. Results: The expression of CD3 and CD34 markers in the peritumoral and intratumoral regions was statistically significant. No significant correlation was found between CD3 and CD34 markers in the peritumoral and intratumoral areas. Conclusion: There is no apparent correlation between T lymphocytes and angiogenesis in the peritumoral and intratumoral areas, however there is a link between the expression of CD3 and CD34 markers in the peritumoral and intratumoral regions.

Keywords: Oral squamous cell carcinoma, T lymphocytes, Angiogenesis, CD3 marker, CD34 marker

Medical Science, 2020, 24(103), 1239-1246

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