Volume 24, Issue 103, May - June, 2020

Are higher serum levels of myoglobin and creatine kinase enzymes indicative for progressive cardiovascular disease among patients with type 2 diabetes?

Elyasa Mustafa Elfaki¹, Fauwaz Fahad Al rashid², Hussain Gadelkarim Ahmed^2,3,4♦

¹Clinical Laboratory Sciences, College of Applied Medical Science, Al-Qurayyat, Jouf University, Saudi Arabia.
²College of Medicine, University of Hail, Saudi Arabia.
³Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha’il, KSA.
⁴Department of Histopathology and Cytology, CMLS, University of Khartoum, Sudan.

^♦Corresponding author
Prof. Hussain Gadelkarim Ahmed, College of Medicine, University of Hail 2440, Saudi Arabia. Email: hussaingad5@gmail.com

ABSTRACT

Objective: The purpose of this study was to evaluate serum myoglobin as a cardiac muscle marker for the detection of early cardiovascular disorder and to assess total Creatine Kinase(CK) and creatinekinase-MB (CK-MB) levels among patients with Type 2 Diabetes mellitus (T2DM). Methodology: In this study, 300 study subjects were divided into two groups; 200 subjects diagnosed with T2DM (ascertained as cases) and 100 healthy individuals (ascertained as control group). Results: Significant increases in the serum levels of myoglobin, glucose, HbA1c, total creatine kinase and creatine kinase isoenzyme MB (CK-MB) were observed in diabetic patients compared to levels in healthy individuals. Besides, a significant increase in myoglobin, total CK and CK-MB levels was observed among diabetic patients with ischemic heart disease or hypertension. Moreover a strong positive correlation was observed between the duration of diabetes and the serum levels of myoglobin, total CK and CK-MB (r = 0.80, P = 0.00; r = 0.68, P = 0.030; and r=0.78, P= 0.000, respectively). Additionally, the present study showed significant positive correlations between the body mass index (BMI) of diabetic patients and the serum levels of myoglobin, total CK and CK-MB (r=0.77, P=0.000; r=0.65, P=0.028; and r=0.76, P=0.000. respectively). However, this study showed insignificant weak positive correlations between HbA1C and the serum levels of myoglobin, total CK and CK-MB (r=0.28, P=0.068; r=0.27, P=0.075; and r=0.37, P=0.066, respectively). Conclusion: The higher levels of myoglobin, CK and CK-MB may be indicative of progressive cardiovascular disease among diabetic patients.

Keywords: Glucose, cardiovascular diseases, myoglobin, creatine kinase, diabetes mellitus, HbA1c

Medical Science, 2020, 24(103), 1230-1238

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