ARTICLE
Sperm cells and reproductive hormones abnormalities associated with Terminalia catappa (Indian almond) leaf extract administration in streptozotocininduced diabetic male Wistar rats
Ezekiel E Ben, Asuquo E Asuquo, Udeme A George, Haruna O Suleiman, Abayomi A Taiwo, Caleb A Jonah
Incidences of toxicity of some therapeutic substances on other parts of the body while producing her usefulness are not strange in the management of disease conditions.
Drug Discovery, 2024, 18(42), e14dd1987
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Alcohol-induced neurotoxicity and mitigating effect of Trichocereus macrogonus stem-sap on the amygdala of Wistar rats
Ini-Obong G Essien, Christopher C Mbadugha, Aquaisua N Aquaisua
Alcohol is known to have neurotoxic effects on the brain, particularly on the amygdala, a pertinent brain structure for emotional processing, learning, memory, and social behavior
Drug Discovery, 2024, 18(42), e15dd1989
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In experimental animals, Medicago sativa ethanol leaf extract reduces pains and inflammation
Anele Donatus Onyebuchi, Ofonakara Uzochukwu, Nwokike Matthew Onyemaechi, Austin-Abu Jane Uchenna, Asogwa Rosemary Ekene, Igwe Divine Okemefuna, Ajegi Innocent Fountain, Ofor Casimir Chijioke, Akuodor Godwin Christian
The well-known medical herb Medicago sativa has long been recommended as a pain reliever. In this work, the analgesic and anti-inflammatory properties of the leaf were examined in rodents
Drug Discovery, 2024, 18(42), e16dd1991
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Long-term neuroprotective efficacy of VEMSA-PD nasal drops: An innovative approach for management and mitigation of Parkinson’s disease symptoms
Muralidhar S Talkad, Aamir Javed, Vijay Satish, HV Anil Kumar, Kamal Saba
Background and Purpose: Parkinson's Disease (PD) is a neurodegenerative disorder primarily affecting dopamine-producing neurons in the brain, leading to a spectrum of motor and non-motor symptoms. Methods: This study introduces VEMSA-PD nasal drops as a potential candidate, which, based on our investigations, has shown promising neuroprotective properties
Drug Discovery, 2024, 18(42), e17dd1993
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Acute and sub-acute toxicity study of Lonchocarpus laxiflorus leaf methanol extract on albino rats
Abubakar Abdulhamid, Angela Nnenna Ukwuani-Kwaja, Hussain Mustapha Hassan, Abdulhamid Zubairu, Hassan Ibrahim Namaki, Sanusi Ibrahim Mungadi
Toxicology is the vital part of pharmacology which deals with the undesirable effect of phytocompounds on living organisms before they are use as drug or chemical in clinical use. This study is aimed at evaluating the acute and sub-acute toxicity effects of Lonchocarpus laxiflorus leaf methanol extracts (LLMLE).
Drug Discovery, 2024, 18(42), e18dd1999
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An Investigation of Crinum jagus Bulbs for Lead Anti- Hepatocellular Carcinoma Compounds
Taye Alawode, Labunmi Lajide
Hepatocellular carcinoma is one of the primary causes of cancer-related mortality. In this study, we evaluated the anticancer activity of five chromatographic fractions derived from the methanol extract of Crinum jagus bulbs against the HepG2 hepatocellular carcinoma cell line, using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) assay.
Drug Discovery, 2024, 18(42), e19dd2003
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Investigation of the in-vitro and invivo hypoglycemic potential of musa paradisiaca l. (ab) and mangifera indica l. Inflorescences
Silpa IS, Akila E, Krishna Murthy, Neha KB, Kashifa Farheen
Objective: This study aims to investigate the hypoglycemic effects of the inflorescences of Musa paradisiaca L. (AB) and Mangifera indica L., exploring their in-vitro and in-vivo antidiabetic potential.
Drug Discovery, 2024, 18(42), e20dd2011
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Biosynthesis of gold nanoparticles from Amaranthus gangeticus and its anti-diabetic activity on streptozotocin induced rats
Akila Elias, Prasanna V Habbu, Sudhir Iliger
Introduction: Diabetes mellitus is a metabolic disease that causes high blood sugar which causes impairment in parts of the body like nerves, eyes, kidneys, and other organs. The treatment using Oral antihyperglycemics can cause many adverse effects and if given in combination, can lead to drug-drug interactions
