Volume 17, Issue 39, January - June, 2023

Neurocognitive and neuroprotective potential of Mimusops elengi in mice model of scopolamine-induced amnesia

Jayaraman Rajangam^1♦, Dharani Prasad Parthasaradhi², Muddukrishnaiah Kotakonda³, Narahari N Palei¹, Alagusundaram Muthumanickam⁴, Navaneetha Krishnan Subramanam⁵, Hima Bindhu⁵

¹AMITY Institute of Pharmacy, AMITY University, Lucknow, Uttar Pradesh-226028, India
²Sree Vidyanikethan College of Pharmacy - Tirupati, Andhra Pradesh-517501, India
³Faculty of Technology, Anna University, Chennai-600025, India
⁴School of Pharmacy, ITM University, Gwalior, Madya Pradesh- 474001, India
⁵Kalam College of Pharmacy, Tanjore-600025, India

^♦Corresponding author
Professor, Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh-226028 India

ABSTRACT

The study was aimed to assess the cognitive and protective potential of methanol extract of Mimusops elengi bark (MEME-B) and flowers (MEME-F) against a mice model of the amnesia paradigm. Scopolamine (3 mg/kg i.p) was used to induce amnesia and treatment with MEME-B and MEME-F extract (200mg/kg p.o) was continued for 21 days. To examine cognitive parameters, the elevated plus maze (EPM) and Morris water maze (MWM) tests were used, whilst serum samples and tissue brain homogenate were used to investigate biochemical and antioxidant data along with morphometric factors. The obtained data reveal that scopolamine caused a substantial increase in transfer latency on days 14 and 21 in the EPM model, which was reversed (p < 0.05) by both MEME-B and MEME-F. Similarly, in the MWM test, extract-treated mice showed a steady decrease in escape latency time (p < 0.05). The findings confirm that scopolamine impairs learning and memory, whereas the administration of MEME-B and MEME-F significantly ameliorated scopolamine-induced amnesia in both the EPM and MWM test, as indicated by significant (p < 0.05) reductions in transfer latency (TL) and escape latency (EL). The considerable restoration of biochemical markers such as acetylcholinesterase (AChE) and antioxidants such as super oxide dismutase (SOD) and (CAT) further corroborated the findings. In conclusion, MEME-F has demonstrated a significant neurocognitive property against scopolamine-induced amnesia, as evidenced by significant inhibition of AChE activity to a significant extent with significant reduction of transfer latency and escape latency, whereas MEME-B has demonstrated significant neuroprotective activity, which could be attributed to its significant antioxidant property.

Keywords: Mimusops elengi, amnesia, neuroprotection, scopolamine, transfer latency, escape latency

Drug Discovery, 2023, 17(39), e7dd1008

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DOI: https://doi.org/10.54905/disssi.v17i39.e7dd1008

Published: 09 February 2023