Volume 17, Issue 39, January - June, 2023

A curcumin loaded niosomes as novel drug delivery system by ether injection method

Chelsea Ruth John¹, Abbaraju Krishna Sailaja¹

¹Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Affiliated to Osmania University, Hyderabad, India

ABSTRACT

Curcumin is a natural chemical which is produced by a plant called Curcuma longa species. Curcumin has been shown to be an antioxidant, anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anti-cancer activity. But the chemical structure of curcumin shows poor stability, low solubility and rapid degradation. To overcome this problem a novel niosomal drug delivery system was developed. Niosome vesicles are composed of cholesterol and non-ionic surfactants, in which both amphiphilic and lipophilic drugs can be encapsulated. It is a novel drug delivery in which the drug delivers to its target site. These are similar to liposomes but show more advantages over them. This article shows improving Stability, Solubility, its advantages and disadvantages, Methodology, characterization and evaluation of curcumin by niosomal formulation. In this study drug content was found to be 8.04mg/ml, Entrapment efficiency was found to be 95.2% and the percentage of drug release was 34.5% at 4^th hour.

Keywords: Niosomes, Ether Injection Method, Novel Drug Delivery System, Curcumin

Drug Discovery, 2023, 17(39), e19dd1918

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DOI: https://doi.org/10.54905/disssi.v17i39.e19dd1918

Published: 18 April 2023