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Volume 59, Issue 329, May 2023

About the Cover

Cannabis is used by Parkinson’s disease (PD) patients. Therefore, the present study investigated oxidative stress and neurodegeneration in brain subsequent to treatment with Cannabis sativa extract. The rat model of PD induced by intrastriatal injection of lipopolysaccharide (LPS) was used for this purpose. LPS or vehicle was injected into the striatum and rats were then treated daily for 15 days with cannabis extract at doses of 5, 20, 20 or 40 mg/kg (expressed as delta-9-tetrahydrocannabinol). Biochemical markers of oxidative stress and tumour necrosis factor-α (TNF-α) were determined besides brain histopathology and caspase-3 expression. Results showed that intrastriatal LPS increased oxidative/nitrosative stress indicated by increased malondialdehyde (MDA) and nitric oxide combined with decreased reduced glutathione (GSH) and paroxonase-1 (PON-1) activity in different brain regions. There were also decreased striatal levels of glutathione peroxidase (GPx) and increased TNF-α. LPS caused neuronal necrosis and apoptosis and intense caspase-3 immunostaining. Cannabis treatment decreased the elevated MDA and nitric oxide levels while increasing GSH and PON-1 activity in different brain regions. Cannabis also increased GPx activity and markedly reduced TNF-α in the striatum.

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SCIENCE

Application of geo-electric indices in groundwater vulnerability mapping: A case study of Agbor, Delta State, southern region Nigeria

Omajene Aghogho, Ighrakpata F, Umayah OS

To identify the aquifer protection and groundwater potential of the aquifer in Agbor and its surroundings, Delta State, Nigeria, an electrical resistivity approach was used.

Discovery, 2023, 59(329), e51d1210

Abstract | PDF

Performance of growing West African dwarf (wad) goats fed rice bran replacement for cassava peel in pelleted diets

Samuel Olawoye, Funmilayo Okeniyi, Olayinka Alabi, Razaq Animashahun, Micheal Falana, Precious Ocheli, Yinka Omotosho, Samuel Olatundun, Moji Adeniran

The selective picking of some non-conventional feedstuffs by goat during feeding called for pelleting technique to improve intake and performance. Sixteen growing (WAD) goats in complete randomized design.

Discovery, 2023, 59(329), e52d1211

Abstract | PDF

Attitude of smallholder farmers towards production of fortified Vitamin A Cassava in Oke-Ogun area of Oyo State

Eniola PO, Adeleke OA, Ologundudu OM, Adekola OA

This study investigates the constraints encountered by smallholder farmers in the production of fortified vitamin A cassava in Oke-Ogun Area of Oyo State. Purposive sampling procedure was used to select 108 respondents.

Discovery, 2023, 59(329), e53d1220

Abstract | PDF

Influence of zinc on germination of maize (Zea mays) germplasm under saline stress condition

Zain-Ul-Sajjad, Zohaa Fatima, Sheikh Muhammad Ijaz, Rizwan Abbas, Muhammad Bilal, Muhammad Subhan, Sharaft Hussain

The present study is an experimental investigation of the effects of varying rates of zinc application on maize germplasm under salt stress conditions. The experiment was conducted at Arid University Rawalpindi.

Discovery, 2023, 59(329), e54d1227

Abstract | PDF

Effect of thiourea on germination and seedling parameters of millet germplasms under drought stress

Zohaa Fatima, Zain-Ul-Sajjad

Pearl millet plays an important role in livestock feeding. In our country, fodder or livestock feed production is less as compared to other countries. For getting quality yield, nitrogen element is necessary for fodder crops.

Discovery, 2023, 59(329), e55d1229

Abstract | PDF

Potential cancer and non-cancer hazard of some heavy metals in children and adults via consumption of canned chicken luncheon and Turkey luncheon

Douye P Markmanuel, Jackson Godwin, Abinotami W Ebuete

Canned meat products contain essential nutrients and trace mineral elements required for human adequate diet. However, most materials used for coating canned meat and other canned food products are often metals.

Discovery, 2023, 59(329), e56d1237

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MEDICINE

Knowledge regarding uterine prolapse among reproductive age group women of Birendranagar, Surkhet, Nepal

Giri S

Uterine prolapse is one of the most common causes of reproductive morbidity which influence the women quality of life

Discovery, 2023, 59(329), e57d1246

Abstract | PDF

Effect of cannabis in the intrastriatal lipopolysaccharide model of Parkinson’s disease in the rat

Omar ME Abdel-Salam, Eman R Youness, Enayat A Omara, Amany A Sleem

Cannabis is used by Parkinson’s disease (PD) patients. Therefore, the present study investigated oxidative stress and neurodegeneration in brain subsequent to treatment with Cannabis sativa extract.

Discovery, 2023, 59(329), e58d1228

Abstract | PDF

Effectiveness of Buerger Allen exercise among pregnant women with Restless leg syndrome in a selected hospital Banke, Nepal

Srijana Sapkota

Background: Restless Leg Syndrome is a neuromuscular sensorimotor disorder characterized by uncontrolled urge to move the affected legs which is accompanied by distressing parathesia.

Discovery, 2023, 59(329), e59d1230

Abstract | PDF

SOCIAL SCIENCE

Economic analysis of poverty trend in Nigeria from 1980–2018

Ayalogu Nkiru Vivian, Robinson MO, Kalu Ijeoma Emele

Poverty has been an issue from times past. People have wondered why individuals have been unable to break free from the shackles of poverty. This paper looks at the possible causes of poverty.

Discovery, 2023, 59(329), e60d1222

Abstract | PDF
Creative Commons License

© The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution License 4.0 (CC BY 4.0).