DISCOVERY

• Home
• Archive
• Aim & Scope
• For Authors
• Manuscript Submission
• Contact Us

Volume 59, Issue 326, February 2023

About the Cover

Nuclear factor kappa-B (NF-κB) is transcription factor that controls the expression of several genes involved in inflammation and immunity. The aim of the present study was to evaluate the levels of NF-κB in brain and serum of rats treated with Cannabis sativa resin, tramadol or their combination. Rats were treated with cannabis resin extract (5, 10 or 20 mg/kg) (expressed as Δ⁹-tetrahydrocannabinol), tramadol (5, 10 or 20 mg/kg) or tramadol (10 mg/kg) combined with cannabis (5, 10 or 20 mg/kg) subcutaneously (s.c.) once a day, for 6 weeks. Results showed that NF-κB was significantly increased in the brain by 21.8-84.3% after treatment with 5-20 mg/kg cannabis and in serum by 37.7% and 70.8% after treatment with 10 or 20 mg/kg cannabis. NF-κB was also significantly increased in the brain by 25.7-48.2% following treatment with 5-20 mg/kg tramadol and in serum by 34.8% after 20 mg/kg tramadol. After the combined administration of both cannabis and tramadol, NF-κB levels were significantly raised in the brain by 45.5-101.2% and in serum by 40.7-91.8%. The increase in brain tissue and serum levels of NF-kB in rats treated with cannabis and/or tramadol suggest that NF-κB may play a role in the pathogenesis of neuronal injury by these drugs of abuse. (Ref: Abdel-Salam OME, Youness ER. Increased brain and serum nuclear factor kappa-B levels by cannabis and tramadol. Discovery 2023; 59: e19d1015).

Table of Contents

Previous | Next

SCIENCE

Variations in soil pH, N, P and K due to influence of rates, split applications of nitrogen fertilizer and ratoon crop of sugarcane varieties

G Oindo Achieng, P Okinda Owuor, C Ogutu Omondi, G Onyango Abayo

Fertilizer Best Management Practices (BMPs) include soil testing that is performed to determine the availability of essential elements for profitable and productive yields of crops.

Discovery, 2023, 59(326), e13d1013

Abstract | PDF

Relish of Beng saga (Centella asiatica (L.) Urb.): A nutraceutical food of the Bhuian tribe

Sradha Swarupa Nayak, Sanath Kumar N, Sanjeet Kumar

The number of diseases and disorders is increasing day-by-day. Therefore, proper nutrition and medicines have become a major necessity for mankind. Synthetic medicines have side effects.

Discovery, 2023, 59(326), e14d1014

Abstract | PDF

Diversity of weed flora of eight selected crop fields in Joypurhat district of Bangladesh

Md Mozahidul Islam, AHM Mahbubur Rahman

From October 2021 to September 2022, weed flora variation was studied in eight selected crop fields in the Joypurhat district of Bangladesh. These fields included rice, wheat, potato, maize, brinjal, chili, black gram and sugarcane.

Discovery, 2023, 59(326), e15d1017

Abstract | PDF

First photographic record of albinism in chital (Axis axis) from Chitwan National Park, Nepal

Abhinaya Pathak, Arjun Tamang, Bishal Sintan, Sujan Khanal, Bikash Pathak, Prashamsa Paudel

Chital or spotted deer (Axis axis) is one of the important cervid in Chitwan National Park of Nepal. They are easily observed roaming around. However, albino chital is barely found in the park.

Discovery, 2023, 59(326), e16d1018

Abstract | PDF

Aquatic vascular flora at Sadar Upazila of Chapai Nawabganj district, Bangladesh

Md Haiule Basar, AHM Mahbubur Rahman

The current study concentrated on the aquatic plants and their conservation status in both naturally occurring and artificially created wetlands across Chapai Nawabganj Sadar Upazila.

Discovery, 2023, 59(326), e17d1019

Abstract | PDF

ENGINEERING

On the two different formulations of mechanical energy in driven oscillations

Jeong Ryeol Choi, Ji Nny Song

We introduce two different formulae of mechanical energy of harmonic oscillators driven by an external force in this work. In the first formula, the energy is composed of two terms.

Discovery, 2023, 59(326), e18d1023

Abstract | PDF

MEDICINE

Increased brain and serum nuclear factor kappa-B levels by cannabis and tramadol

Omar ME Abdel-Salam, Eman R Youness

Nuclear factor kappa-B (NF-κB) is transcription factor that controls the expression of several genes involved in inflammation and immunity. The aim of the present study was to evaluate the levels of NF-κB in brain and serum of rats.

Discovery, 2023, 59(326), e19d1015

Abstract | PDF

Review of cases of diarrhea among infants in Africa: Causative organisms, detection methods and infant age distribution

Abidemi David Adetulubo, Oluwole Moses David, Pius Olalekan Adeola

Diarrhoea is one of the most common health problems in Africa. This faecal-orally transmitted disease is responsible for the death of 1.9 million children under five years with a high proportion from resource-poor nations.

Discovery, 2023, 59(326), e20d1016

Abstract | PDF

SOCIAL SCIENCE

Implementation challenges of enterprise resource planning systems in the Tanzania mining industry: Evidence from Barrick mining company Tanzania

Richard Mbogo, Juma Mshana

The study assessed the implementation challenges of ERP systems in the Tanzania mining industry. Mixed research approach was employed, in that regard, case study design was used.

Discovery, 2023, 59(326), e21d1020

Abstract | PDF

Effect of national internet data center colocation service on digital transformation in Tanzania

Lilian H Mungure, Juma Mshana

The study assessed the effect of NIDC (National Internet Data center) colocation service on digital transformation in Tanzania. The study specifically focused on the effect of NIDC colocation on digital infrastructure.

Discovery, 2023, 59(326), e22d1021

Abstract | PDF

Challenges hindering effective implementation of sciences, maths and ICT in secondary schools in Tanzania

K A Nihuka

This study investigated challenges that still hinder effective implementation of sciences, maths and ICT subjects from head of schools’ perspective despite recent significant investments in secondary schools in Tanzania.

Discovery, 2023, 59(326), e23d1022

Abstract | PDF