Volume 30, Issue 175, September 2026

Clinical applications of platelet-rich fibrin (PRF) in dentistry and oral surgery: A review of the literature

Daria Wieczorek^♦, Adrianna Chachuła, Natalia Kruk, Izabela Ślusarczyk, Jan Olszewski, Julia Rojek, Patrycja Jędrzejewska, Szymon Uszak, Wojciech Szlajss, Tomasz Szczawiński

Medical University of Lodz: Lodz, Łódź Voivodeship, Poland

^♦Corresponding author
Daria Wieczorek, Medical University of Lodz: Lodz, Łódź Voivodeship, Poland

ABSTRACT

Platelet-rich fibrin (PRF) is a biomaterial obtained from patients themselves. That made it an essential material in oral and maxillofacial surgery due to its effectiveness in stimulating tissue repair. PRF is obtained from the patient’s blood through a simple centrifugation process—without the addition of anticoagulants— that creates a fibrin scaffold filled with platelets, white blood cells, and growth factors. These biological elements play a major role in angiogenesis and stimulation cells to multiply while healing. Lately, working with PRF has gained popularity because it is easy and relatively cheap. Also, it helps achieve better results in many dental procedures. We created this review to take a closer look at the latest research about PRF production, characteristics, and how it is used in clinical work. We searched through databases such as PubMed and Scopus to select the most relevant works from the last few years. Our review focuses on how PRF performs in socket healing, implant placement, bone grafting, and gum surgery. Research indicates that work with PRF can actually support wound healing, improve bone growth, and alleviate common postoperative problems such as pain or swelling. Therefore, it looks promising in implantology and gum treatment. Many clinicians are using slightly different preparation methods and we still lack enough clinical trials so we still need more research. Overall, PRF remains a material with great potential to improve the way we manage patients in modern dental clinics.

Keywords: PRF, platelet-rich fibrin, oral surgery, dentistry, regenerative therapy

Medical Science, 2026, 30, e181ms3915

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Published: 03 September 2026