Volume 30, Issue 168, February 2026

Dementia with Lewy Bodies: Diverse Signs and Symptoms, Diverse Therapeutic Approaches - A Review of the Literature

Jakub Molenda^1♦, Adrianna Klimczak¹, Barbara Pietrzak¹, Mikołaj Patelski¹, Maciej Czapla², Mateusz Surma², Marta Kamińska³, Matylda Kuczma³, Wiktoria Mikusek³, Wiktoria Kotlarz³, Krzysztof Dobrzeniecki⁴

¹Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznan, Greater Poland, Poland
²Prof. S. T. Dąbrowski Hospital in Puszczykowo S.A., 11 Józefa Ignacego Kraszewskiego Street, 62-040 Puszczykowo, Greater Poland, Poland
³Medical Center HCP, 28 Czerwca 1956 r. 194, 61-485 Poznan, Greater Poland, Poland
⁴Poznan University of Medical Sciences: Poznan, Poland

^♦Corresponding author
Jakub Molenda; Heliodor Swiecicki Clinical Hospital: Poznan, Greater Poland, PL

ABSTRACT

Dementia with Lewy bodies belongs to the most common neurodegenerative diseases; however, it is frequently misdiagnosed or underdiagnosed due to its broad spectrum of clinical signs and symptoms. The spectrum of possible clinical presentations is rather vast and encompasses not only diverse cognitive impairments and sleep disturbances but also Parkinsonian features, autonomic dysfunction, and psychiatric manifestations. To date, there is no treatment available that halts disease progression, and no single medication can address all its symptoms. Taking it into consideration, clinicians must treat every single symptom separately, often using multiple pharmacological interventions. It is important to bear in mind that every medication carries the possible risk of adverse effects, which may require dose reduction or even necessitate discontinuation of therapy. This review highlights the range of available treatment options for this type of dementia and calls for further research to address patients’ needs and improve disease management.

Keywords: dementia with Lewy bodies, Lewy body dementia, dementia management, dementia treatment

Medical Science, 2026, 30, e34ms3776

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DOI: https://doi.org/10.54905/disssi.v30i168.e34ms3776

Published: 18 February 2026