Introduction & Objective: Chronic rhinosinusitis is one of the most common chronic diseases which involve12 to 17 percent of the
population. Topical treatments like irrigation and inhalation may have a role in affecting the biofilms and so can be effective in
treating chronic infection and chronic rhinosinusitis. The purpose of this study was to determine the effectiveness of using apple
cider vinegar in the treatment of patients with chronic rhinosinusitis with or without polyposis. Methods: In the present study, 100
patients with chronic rhinosinusitis in the age range of 25 to 54 years with a mean age of 35.3 years were included. They were
divided into control and intervention groups. SNOT-22 questionnaire was used to evaluate the complications and symptoms of
rhinosinusitis. For grading polyposis Meltzer grading criterion was used collected data were entered into SPSS 20 software and
analyzed by Chi square test. The normality of the mean distributions was assessed using Kolmogorov-Smirnov test. Results: There
was no significant difference between the age and sex in the two groups and the two groups were homogeneous. In the present
study, the results of the chi-square test showed that there was a statistically significant difference between the two groups
(P=0.001). In the control group, sinus outcome was more severe. Also the result of independent t-test showed that there was a
statistically significant difference between the two groups in the mean score of sinus outcome (P=0.007). The average scores of sinus
outcome before and after the intervention were significantly difference (P = 0.001). So that the mean score of the sinus outcome
after the intervention (45.98) it was lower than before the intervention (53.4). So overall after intervention, severity of outcome and
complications of sinusitis in both intervention and control groups decreased. But this decline in the intervention group had more
than the control group and this difference been statistically significant. Conclusion: apple cider vinegar may effectively improve the
symptoms of rhinosinusitis. Considering the low cost of apple cider vinegar, its availability and easily to perform inhalation without
special equipment; it can be recommended as a complementary supplement to routine treatments for patients with rhinosinusitis.
Keywords: apple, Vinegar, Inhalation, Rhinosinusitis, Chronic