Volume 24, Issue 104, July - August, 2020

The antioxidant impact of Saudi sidr honey against acetyl salicylic acid- induced gastric ulcer

Ghadeer Al-Ghamdi¹, Rasha H. Hussein^1,2, Reem Al-azragi¹

¹Biocehmistry Department, Faculty of Sceince, University of Jeddah, KSA
²Department of Biochemistry and Nutrition, Women Faculty for Arts, Science and Education, Ain Shams University, Egypt

ABSTRACT

It was mostly known that nonsteroidal anti-inflammatory drugs (NSAIDs) frequently be a main cause of gastric ulcers (GUs). Honey market is reaching a notable advance due to the strong cultural, social and religious relation between people and using honey. This study investigated the protective effects of Saudi sidr honey on aspirin induced gastric ulcer in rats. Rats were divided into three groups, G1, Healthy negative control. G2: Gastric ulcer rats, ulcer was induced by 4 doses of Aspirin taken orally (200 mg/kg b.w) G3: Saudi Sidr Honey group after induction of gastric ulcer, Sidr honey was administered in the dose. Results showed that Aspirin induced oxidative stress in gastric tissues that manifested by decreased levels of superoxide dismutase (SOD), reduced glutathione (GSH), together with increased levels of malondialdehyde (MDA) and xanthine oxidase (XO). Our results showed using Saudi Sidr honey modified the results and reduced oxidative stress. For this reason it posses an antioxidant protective role against gastric ulcer.

Keywords: Gastric ulcer, Aspirin, Saudi sidr honey, Oxidative stress

Medical Science, 2020, 24(104), 1923-1929

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