It was mostly known that nonsteroidal anti-inflammatory drugs (NSAIDs) frequently be a main cause of gastric ulcers (GUs). Honey
market is reaching a notable advance due to the strong cultural, social and religious relation between people and using honey. This
study investigated the protective effects of Saudi sidr honey on aspirin induced gastric ulcer in rats. Rats were divided into three
groups, G1, Healthy negative control. G2: Gastric ulcer rats, ulcer was induced by 4 doses of Aspirin taken orally (200 mg/kg b.w) G3:
Saudi Sidr Honey group after induction of gastric ulcer, Sidr honey was administered in the dose. Results showed that Aspirin
induced oxidative stress in gastric tissues that manifested by decreased levels of superoxide dismutase (SOD), reduced glutathione
(GSH), together with increased levels of malondialdehyde (MDA) and xanthine oxidase (XO). Our results showed using Saudi Sidr
honey modified the results and reduced oxidative stress. For this reason it posses an antioxidant protective role against gastric ulcer.
Keywords: Gastric ulcer, Aspirin, Saudi sidr honey, Oxidative stress