Volume 24, Issue 103, May - June, 2020

Cerebroprotective effect of Quercetin in Ischemia/reperfusion-induced oxidative stress in rats

Abdulrahman M. Alshahrani

Department of Internal Medicine (Neurology), College of Medicine, Shaqra, Shaqra University, Shaqra-11961, Saudi Arabia
ORCID: https://orcid.org/0000-0001-8814-9333; Email: alshahrani.md@su.edu.sa

ABSTRACT

The most common causes of cerebrovascular disorders are ischemia/reperfusion (I/R) injury, stroke, and chronic hypo perfusion. Quercetin is a plant pigment that is reported to protect against stress. Objective: This research protocol was designed to evaluate the protective properties of quercetin in cerebral ischemia/reperfusion injuries. Method: Adult male rats were divided into four groups randomly (sham, quercetin, I/R, and I/R with quercetin). The induction of cerebral ischemia was done through the ligation of bilateral common carotid arteries for 30 minutes; then, reperfusion was allowed for four hours. Result: Quercetin ameliorates the harmful effect of I/R by reducing the oxidative stress. It reduced the high level of inflammatory cytokines, TNF-α and NF-κB, and improved the level of Bcl2. Conclusion: The present study reveals that quercetin protects the cerebral cortex against the injuries caused by I/R through its anti oxidative, anti-inflammatory and anti apoptotic effects. Furthermore, the results also suggest that the quercetin represents a hopeful therapy for neurological diseases due to oxidative stress and I/R.

Keywords: Quercetin, antioxidant, ischemia and reperfusion, oxidative stress, cerebral injury

Medical Science, 2020, 24(103), 1350-1360

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