Odontogenic keratocyst (OKC) is a developmental cyst arising from the enamel organ or the dental lamina. It commonly affects
males in their 2nd - 4th decade and is associate with a high recurrence rate of 2.5 – 62 %. The treatment of OKC depends on the size
of the lesion, with conservative approaches like enucleation with or without adjuvant therapies, marsupialisation indicated in smaller
lesion For extensive lesions, however, en bloc resection is the choice of treatment. The reconstruction of continuity defect formed
following en bloc resection has always remained a question for the surgeons, with options being free tissue transfer, titanium
implants and patient specific implants. Polyether etherketone (PEEK) is one such biocompatible alloplastic material recently
introduced for the reconstruction of such discontinuity defects in the maxillofacial skeleton. We present a case of reconstruction of
discontinuity defect following en bloc reception of OKC of right mandibular body and ramal region using PEEK.
Keywords: Odontogenic Keratocyst; Mandibular reconstruction; Patient specific implant; DICOM; PEEK