Many preclinical trails on laboratory rats have well demonstrated the effects of unpredictable stressors that they produce behavioral and neurochemical alterations. Chronic stress produces the alteration in serotonergic transmission it has potential to increase the responsiveness to drug challenges and novel stressors to behavioral and neurochemical alteration. The present study was performed to determine the antidepressant potential of methylphenidate in animal model of chronic mild stress. The experimental case-control study was conducted in April 2015 at the Department of Biochemistry, University of Karachi and comprised male rats. Average weight rats were randomly divided into two equal groups, animal of stressed group were exposed to CMS. Animals of unstressed and stressed group were administrated with methylphenidate at dose 1.0 mg/kg/day for 14 days 1 hour before the animals exposed to CMS. Behavioral anxiolytic assessments were done by using light/dark transition and elevated plus maze apparatus models. CMS exposed animals showed behavioral deficits, which recovered by the repeated administration of methylphenidate treatment. Animals showed anxiogenic deficit on repeatedly exposure to stress as compared to unstressed animals which were attenuated by repeated administration of methylphenidate.
Particulate matter air pollution, both indoor and outdoor, although traditionally causally associated with pulmonary disease, is now being increasingly implicated in cardiovascular disease and mortality.
Many preclinical trails on laboratory rats have well demonstrated the effects of unpredictable stressors that they produce behavioral and neurochemical alterations. Chronic stress produces the alteration in serotonergic transmission it has potential to increase the responsiveness to drug challenges and novel stressors to behavioral and neurochemical alteration.
Tracheo-bronchial foreign body aspiration is a life threatening condition that can be seen in all age groups. Tracheostomy is a common lifesaving airway procedure. This procedure is although safe, early and late complications are known to occur.
The aim of this study was to assess the dietary intake of female patients with renal failure in Al-Hassa Province, east of Saudi Arabia, and to study the effect of some variables on dietary intake of the patients.
We recommend the use of a radio guided bilateral neck exploration with the evaluation of the functionality of the four parathyroid glands to determine which should be excised for the management of primary hyperparathyroidism (PHPT).
Appropriate detection of Carbapenem Resistant Enterobacteriaceae (CRE) is vital for patient care in order to institute correct therapeutic options. Molecular techniques can easily differentiate classes but the need of the hour is a rapid practical phenotypic method which can differentiate KPCs and MBLs in Enterobacteriaceae.
Monomorphic adenoma is a rare benign salivary gland tumour of epithelial origin representing <2% of all tumours in general population and more than 80% of them arise in major salivary glands, mostly in the parotid gland and rarely in upper lip or buccal mucosa.
The current study was performed for histological and electron microscopic examination of the effects of different doses of dexketoprofen trometamol on liver in rats.
This study was conducted to assess the relationship between peer support and emotional intelligence as descriptive and correlation. Sample of the study consisted of 417 nursing students available and enrolled to Manisa Celal Bayar University Faculty of Health in academic year 2014-2015 and accepted to participate in the research.
