Macrophage stimulating protein (MSP)/HGF-linked protein (HGFL) was simultaneously discovered as a protein stimulating macrophage activity and hepatocyte growth factor (HGF) family protein. MSP is produced by epithelial cells, and its receptor, Ron (Recepteur d’origine nantais), is expressed in stromal cells. Ron and Met, an HGF receptor, are also both family receptors. However, HGF is produced by stromal cells, and Met plays some roles on epithelial cells. Therefore, HGF-Met and MSP-Ron signallings show a reciprocal correlations under physiological condition. Although HGF-Met is a well-known signalling promoting cancer, RON overexpression was also observed in some human cancers that originated from epithelial cells, and SP-Ron signalling has important activities in cancer development. MSP induces invasion, metastasis, and drug resistance of cancer cells. Moreover, Ron interacts with Met and the EGF receptor, and they exert various effects in cooperation to achieve malignancy. Ron could be an important target of cancer therapy using monoclonal antibodies and small chemical inhibitors. In this review, we focus on the roles of MSP in cancer development and therapies against MSP-Ron-signal-positive cancers (Ref: Takashi Kato. MSP-Ron signalling in cancer treatment. Medical Science, 2017, 21(85), 114- 118); (Image: s3-eu-west-1.amazonaws.com).
Macrophage stimulating protein (MSP)/HGF-linked protein (HGFL) was simultaneously discovered as a protein stimulating macrophage activity and hepatocyte growth factor (HGF) family protein. MSP is produced by epithelial cells, and its receptor, Ron (Recepteur d’origine nantais), is expressed in stromal cells.
Suicide is a major public health concern. Although the authors of many studies have examined the neurobiological aspects of suicide, the molecular mechanisms associated with suicidal behavior remain poorly understood, there is increasing evidence that brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF) are involved in the pathophysiology and treatment of depression through binding and activating their cognate receptors trk B and trk A respectively.
In France, colorectal cancer is the third most common cancer in males and the second most common cancer in females. Thyroid metastasis from CRC is rare. The incidence of metastasis to the thyroid gland in autopsy series varies from 4% to 9%, while in clinical series the prevalence of intra-thyroid metastasis is not more than 1%.
Gun violence is one of the important indicators of level of social and mental health. It is a global problem and causes considerable hazards in a developing country like India, where poverty and violence are not uncommon.
Crimean-Congo hemorrhagic fever is a zoonotic viral disease that can be a serious threat to humans. The transmission of the virus is by ticks bite, by direct contact with blood or tissues from infected animals and by humans to humans by infected persons.
The Aim of the study was to determine the prevalence of Supernumerary teeth in population of Bhagalpur district of Bihar. Patients which came for routine Dental checkup and treatment in JLNMC&H during October 2016 to mid-April 2017 were included in the study.
There is a compelling body of evidence relating subclinical chronic inflammation and schizophrenia in adults. Prenatal infections during pregnancy have been shown to be associated with an increased risk of schizophrenia in the offspring during adulthood.
