Volume 20, Issue 45, 2026 (Forthcoming Issue)

About the Cover

Due to the limited metabolomic data of Artemisinin-Based Combination Therapies (ACTs) in endemic regions, the study assessed the metabolomics of recommended ACTs to understand the pattern of adverse effects in experimental animals (mice, rats, guinea pigs, rabbits) and humans using mass spectrometry. Malaria infection was simulated in all the animal models using Plasmodium berghei NK65, patients who had Plasmodium falciparum infection were also selected. ACTs were administered orally in conventional doses. Serum samples were collected and assayed for metabolomic parameters using standard protocols. The most common metabolites that were significantly altered metabolites in all the models were D-glucose, creatinine, glutamate, aspartate, glycine, taurine, eicosapentaeinoyl-glycerol, hexadecanoic acid, amino-butanoate, and L-tyrosine (OPLS-DA). Commonly altered pathways were lipid, amino acid, carbohydrate, and nucleotide (OPLS-DA).

Previous

ARTICLE

Metabolomics of Artemisinin-Based Combination Therapies in experimental animals and humans

Sylvester Aghahowa, Raymond Ozolua, Enitome Bafor, Ambrose Isah, Michael Aghahowa, David Osifo, Philip Obarisiagbon, Paul Aikorogie

Due to the limited metabolomic data of Artemisinin-Based Combination Therapies (ACTs) in endemic regions, the study assessed the metabolomics of recommended ACTs to understand the pattern of adverse effects in experimental animals (mice, rats, guinea pigs, rabbits) and humans using mass spectrometry

Drug Discovery, 2026, 20(45), e1dd3033

Abstract | PDF

GC-MS and In-Silico Assessment of Orange Peel Phyto-compounds as Antimicrobial and Drug-Like Agents

Abalaka ME, Oloninefa SD, Attah F, Jagaba A

Plants are valuable sources for creating new medicines because they contain many natural compounds that can have positive health effects due to their secondary metabolites.

Drug Discovery, 2026, 20(45), e2dd3030

Abstract | PDF

Exploring In silico model to extrapolate the anti-diabetic potential of phytocompounds from Tapinanthus bangwensis in type 2- diabetes treatment

Godwin O Ihegboro, Chimaobi J Ononamadu, Jude Ezeh, Emmanuel C Okoye, Etoro-Abasi Ekanem, Chidimma H Aneke, Divine Imade, Princewwll Odo, Rosemary Jonathan, Hilary Oblia, Marvelous Offuna

The study used computational tools to predict the phytocompounds (Tapinanthus bangwensis) with potential to ameliorate Diabetes Mellitus. Firstly, two extracts was screened for inhibitory activity; α-amylase (α-A), and α-glucosidase (α-G), and antioxidant capacity

Drug Discovery, 2026, 20(45), e3dd3037

Abstract | PDF

Bioactivity-Guided Isolation and In Silico Molecular Studies of Anti Bitis arietans Venom from Faidherbia albida (Delile) A. Chev Root-Bark Extracts

Ibrahim Sani, Angela Nnenna Ukwuani-Kwaja, Amina Yusuf Jega, Abdulhamid Zubairu, Fatima Bello

Snake venoms contain several life-threatening toxins, while conventional therapies are available for the snake envenoming. The limitations of these antivenins have driven recent research toward the isolation and characterization of plant-derived antivenin compounds that complement synthetic antivenins

Drug Discovery, 2026, 20(45), e4dd3039

Abstract | PDF